Preparation of Magnetic Iron Oxide Incorporated Mesoporous Silica Hybrid Composites for pH and Temperature-Sensitive Drug Delivery

Santhamoorthy, Madhappan; Thirupathi, Kokila; Krishnan, Selvakumar; Guganathan, Loganathan; Dave, Sushma; Phan, Thi Tuong Vy; Kim, Seong-Cheol

doi:10.3390/magnetochemistry9030081

Open AccessArticle

Preparation of Magnetic Iron Oxide Incorporated Mesoporous Silica Hybrid Composites for pH and Temperature-Sensitive Drug Delivery

by

Madhappan Santhamoorthy

^1,†,

Kokila Thirupathi

^2,†,

Selvakumar Krishnan

³,

Loganathan Guganathan

⁴

,

Sushma Dave

⁵

,

Thi Tuong Vy Phan

^6,7,*

and

Seong-Cheol Kim

^1,*

¹

School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea

²

Department of Physics, Government Arts and Science College for Women, Karimangalam, Dharmapuri 635111, Tamil Nadu, India

³

Department of Physics, Bannari Amman Institute of Technology, Sathyamangalam, Erode 638401, Tamil Nadu, India

⁴

Department of Physics, Annamalai University, Annamalainagar, Chidambaram 608002, Tamil Nadu, India

⁵

Department of Applied Sciences, JIET, Jodhpur 342802, Rajasthan, India

⁶

Center for Advanced Chemistry, Institute of Research and Development, Duy Tan University, 03 Quang Trung, Hai Chau, Danang 550000, Vietnam

⁷

Faculty of Environmental and Chemical Engineering, Duy Tan University, 03 Quang Trung, Hai Chau, Danang 550000, Vietnam

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Magnetochemistry 2023, 9(3), 81; https://doi.org/10.3390/magnetochemistry9030081

Submission received: 19 February 2023 / Revised: 5 March 2023 / Accepted: 10 March 2023 / Published: 12 March 2023

(This article belongs to the Special Issue Magnetic Nanoparticles: State of the Art and Future Perspectives)

Download

Browse Figures

Versions Notes

Abstract

In clinical applications for cancer treatment, chemotherapy coupled with thermotherapy is highly considered. The development of multifunctional nanocomposite materials is an appealing strategy for use in various applications including biomedical applications. We present the preparation of dopamine-modified mesoporous silica material, in which magnetic iron oxide nanoparticles (FeNP) were grown onto the outer surface via the complexation of iron (Fe(III) and Fe(II)) ions with the dopamine groups modified on the silica hybrid and subsequent chemical reduction approaches. The prepared magnetic iron oxide incorporated with mesoporous silica hybrid composite nanoparticles (FeNP@MSHC NPs) had a large surface area (346 m²/g), pore size (3.2 nm), and pore volume (0.048 cm³/g). The formation of FeNP on the outer surface of the FeNP@MSHC NPs results in superparamagnetic characteristics. Furthermore, the prepared FeNP@MSHC NPs have a high drug (Dox) loading capacity (~62%) as well as pH- and temperature-responsive drug release efficiency. In addition, the MTT assay result shows the biocompatibility of the prepared FeNP@MSHC NPs. As a result, the FeNP@MSHC NPs could be utilized in cancer treatment for pH and temperature-sensitive delivery of chemotherapeutic agents to the target sites.

Keywords: magnetic iron oxide nanoparticles; mesoporous silica hybrid; pH stimuli; drug delivery; cell viability

Share and Cite

MDPI and ACS Style

Santhamoorthy, M.; Thirupathi, K.; Krishnan, S.; Guganathan, L.; Dave, S.; Phan, T.T.V.; Kim, S.-C. Preparation of Magnetic Iron Oxide Incorporated Mesoporous Silica Hybrid Composites for pH and Temperature-Sensitive Drug Delivery. Magnetochemistry 2023, 9, 81. https://doi.org/10.3390/magnetochemistry9030081

AMA Style

Santhamoorthy M, Thirupathi K, Krishnan S, Guganathan L, Dave S, Phan TTV, Kim S-C. Preparation of Magnetic Iron Oxide Incorporated Mesoporous Silica Hybrid Composites for pH and Temperature-Sensitive Drug Delivery. Magnetochemistry. 2023; 9(3):81. https://doi.org/10.3390/magnetochemistry9030081

Chicago/Turabian Style

Santhamoorthy, Madhappan, Kokila Thirupathi, Selvakumar Krishnan, Loganathan Guganathan, Sushma Dave, Thi Tuong Vy Phan, and Seong-Cheol Kim. 2023. "Preparation of Magnetic Iron Oxide Incorporated Mesoporous Silica Hybrid Composites for pH and Temperature-Sensitive Drug Delivery" Magnetochemistry 9, no. 3: 81. https://doi.org/10.3390/magnetochemistry9030081

APA Style

Santhamoorthy, M., Thirupathi, K., Krishnan, S., Guganathan, L., Dave, S., Phan, T. T. V., & Kim, S.-C. (2023). Preparation of Magnetic Iron Oxide Incorporated Mesoporous Silica Hybrid Composites for pH and Temperature-Sensitive Drug Delivery. Magnetochemistry, 9(3), 81. https://doi.org/10.3390/magnetochemistry9030081

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Preparation of Magnetic Iron Oxide Incorporated Mesoporous Silica Hybrid Composites for pH and Temperature-Sensitive Drug Delivery

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI