Gallic Acid Reactive Extraction with and without 1-Octanol as Phase Modifier: Experimental and Modeling

Blaga, Alexandra Cristina; Dragoi, Elena Niculina; Munteanu, Raluca Elena; Cascaval, Dan; Galaction, Anca Irina

doi:10.3390/fermentation8110633

Open AccessArticle

Gallic Acid Reactive Extraction with and without 1-Octanol as Phase Modifier: Experimental and Modeling

by

Alexandra Cristina Blaga

¹,

Elena Niculina Dragoi

¹

,

Raluca Elena Munteanu

¹

,

Dan Cascaval

^1,*

and

Anca Irina Galaction

²

¹

“Cristofor Simionescu” Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iasi, 700454 Iasi, Romania

²

Faculty of Medical Bioengineering, “Grigore T. Popa” University of Medicine and Pharmacy, 700454 Iasi, Romania

^*

Author to whom correspondence should be addressed.

Fermentation 2022, 8(11), 633; https://doi.org/10.3390/fermentation8110633

Submission received: 17 October 2022 / Revised: 4 November 2022 / Accepted: 9 November 2022 / Published: 12 November 2022

(This article belongs to the Special Issue Separation and Purification of Biosynthetic Products)

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Abstract

Gallic acid (GA) is a naturally occurring phenolic acid that can be found in the leaves, roots, flowers, or stems of a wide variety of plant species. It has a broad range of uses in the food and pharmaceutical industries. The objective of this research is to investigate the GA reactive extraction process employing dichloromethane and n-heptane as solvents, 1-octanol as a phase-modifier, and Amberlite LA-2 as an amine extractant dissolved in the organic phase. The separation yield and distribution coefficient data were discussed, along with the analysis of the extraction conditions and the extraction mechanism. Dichloromethane employed as the solvent, 80 g/L Amberlite LA2 used as the extractant, and 10% phase modifier were determined to be the ideal conditions for the reactive extraction onto a biphasic organic-aqueous system. Statistical regression and artificial neural networks (ANNs) established with the differential evolution (DE) algorithm were also used to model and optimize the process.

Keywords: reactive extraction; phase modifier; gallic acid; Amberlite LA2; extraction mechanism

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MDPI and ACS Style

Blaga, A.C.; Dragoi, E.N.; Munteanu, R.E.; Cascaval, D.; Galaction, A.I. Gallic Acid Reactive Extraction with and without 1-Octanol as Phase Modifier: Experimental and Modeling. Fermentation 2022, 8, 633. https://doi.org/10.3390/fermentation8110633

AMA Style

Blaga AC, Dragoi EN, Munteanu RE, Cascaval D, Galaction AI. Gallic Acid Reactive Extraction with and without 1-Octanol as Phase Modifier: Experimental and Modeling. Fermentation. 2022; 8(11):633. https://doi.org/10.3390/fermentation8110633

Chicago/Turabian Style

Blaga, Alexandra Cristina, Elena Niculina Dragoi, Raluca Elena Munteanu, Dan Cascaval, and Anca Irina Galaction. 2022. "Gallic Acid Reactive Extraction with and without 1-Octanol as Phase Modifier: Experimental and Modeling" Fermentation 8, no. 11: 633. https://doi.org/10.3390/fermentation8110633

APA Style

Blaga, A. C., Dragoi, E. N., Munteanu, R. E., Cascaval, D., & Galaction, A. I. (2022). Gallic Acid Reactive Extraction with and without 1-Octanol as Phase Modifier: Experimental and Modeling. Fermentation, 8(11), 633. https://doi.org/10.3390/fermentation8110633

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Gallic Acid Reactive Extraction with and without 1-Octanol as Phase Modifier: Experimental and Modeling

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