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Fermentation 2018, 4(4), 101;

Biotransformation of Ganoderic Acid A to 3-O-Acetyl Ganoderic Acid A by Soil-isolated Streptomyces sp.

Department of Biological Sciences and Technology, National University of Tainan, No. 33, Sec. 2, Shu-Lin St., Tainan 70005, Taiwan
Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan
Biodiversity Research Center, Academia Sinica, Taipei 115, Taiwan
Department of Food Science, National Quemoy University, No. 1, University Road., Jin-Ning Township, Kinmen County 892, Taiwan
Authors to whom correspondence should be addressed.
Received: 22 October 2018 / Revised: 13 November 2018 / Accepted: 28 November 2018 / Published: 1 December 2018
(This article belongs to the Special Issue Fermentation and Bioactive Metabolites)
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The medicinal fungus Ganoderma lucidum contains many bioactive triterpenoids, ganoderic acid A (GAA) being one of the major ones. The present study explored the microbial biotransformation of GAA, isolating 283 strains of soil actinomycetes and determining their abilities to biotransform GAA with ultra-performance liquid chromatography analysis. One positive strain, AI 045, was selected to validate the biotransformation activity. The strain was identified as Streptomyces sp. based on the sequenced 16S rRNA gene. The produced compound obtained from the biotransformation of GAA was purified with the preparative high-performance liquid chromatography method and identified as 3-O-acetyl GAA based on mass and nuclear magnetic resonance spectral data. The present study is the first report that bacteria have the novel ability to biotransform the triterpenoids of fungus G. lucidum. Moreover, the identified 3-O-acetyl GAA is a new triterpenoid product discovered in microbes. View Full-Text
Keywords: actinomycetes; biotransformation; Ganoderma lucidum; ganoderic acid A; Streptomyces actinomycetes; biotransformation; Ganoderma lucidum; ganoderic acid A; Streptomyces

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chang, T.-S.; Ko, H.-H.; Wang, T.-Y.; Lee, C.-H.; Wu, J.-Y. Biotransformation of Ganoderic Acid A to 3-O-Acetyl Ganoderic Acid A by Soil-isolated Streptomyces sp.. Fermentation 2018, 4, 101.

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