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MiRNAs as Novel Adipokines: Obesity-Related Circulating MiRNAs Influence Chemosensitivity in Cancer Patients

1
Biomedical Research Centre, School of Science, Engineering and Environment, Peel Building, University of Salford, Salford M5 4WT, UK
2
Salford Royal Foundation Trust, Clinical Sciences Building, Stott Lane, Salford M6 8HD, UK
*
Author to whom correspondence should be addressed.
Non-Coding RNA 2020, 6(1), 5; https://doi.org/10.3390/ncrna6010005
Received: 10 December 2019 / Revised: 8 January 2020 / Accepted: 11 January 2020 / Published: 23 January 2020
(This article belongs to the Special Issue Non-Coding RNAs: Variations and Disease)
Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream. Recently, circulating adipose-derived microRNAs (miRNAs) have been proposed as a novel class of adipokine, due to their capacity to regulate gene expression in tissues other than fat. Circulating levels of adipokines are known to be altered in obese individuals compared with typical weight individuals and are linked to poorer health outcomes. For example, obese individuals are known to be more prone to the development of some cancers, and less likely to achieve event-free survival following chemotherapy. The purpose of this review was twofold; first to identify circulating miRNAs which are reproducibly altered in obesity, and secondly to identify mechanisms by which these obesity-linked miRNAs might influence the sensitivity of tumors to treatment. We identified 8 candidate circulating miRNAs with altered levels in obese individuals (6 increased, 2 decreased). A second literature review was then performed to investigate if these candidates might have a role in mediating resistance to cancer treatment. All of the circulating miRNAs identified were capable of mediating responses to cancer treatment at the cellular level, and so this review provides novel insights which can be used by future studies which aim to improve obese patient outcomes. View Full-Text
Keywords: obesity; microRNA; miRNA; circulating; cancer; chemosensitivity; chemoresistance obesity; microRNA; miRNA; circulating; cancer; chemosensitivity; chemoresistance
MDPI and ACS Style

Withers, S.B.; Dewhurst, T.; Hammond, C.; Topham, C.H. MiRNAs as Novel Adipokines: Obesity-Related Circulating MiRNAs Influence Chemosensitivity in Cancer Patients. Non-Coding RNA 2020, 6, 5.

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