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Centromeric Non-Coding RNAs: Conservation and Diversity in Function

Department of Biological Sciences, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan
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Non-Coding RNA 2020, 6(1), 4; https://doi.org/10.3390/ncrna6010004
Received: 9 September 2019 / Revised: 16 December 2019 / Accepted: 15 January 2020 / Published: 17 January 2020
(This article belongs to the Special Issue Non-Coding RNA and Intracellular Structures)
Chromosome segregation is strictly regulated for the proper distribution of genetic material to daughter cells. During this process, mitotic chromosomes are pulled to both poles by bundles of microtubules attached to kinetochores that are assembled on the chromosomes. Centromeres are specific regions where kinetochores assemble. Although these regions were previously considered to be silent, some experimental studies have demonstrated that transcription occurs in these regions to generate non-coding RNAs (ncRNAs). These centromeric ncRNAs (cenRNAs) are involved in centromere functions. Here, we describe the currently available information on the functions of cenRNAs in several species. View Full-Text
Keywords: centromere; chromosome segregation; RNP centromere; chromosome segregation; RNP
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Ideue, T.; Tani, T. Centromeric Non-Coding RNAs: Conservation and Diversity in Function. Non-Coding RNA 2020, 6, 4.

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