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Long Non-Coding RNA in Vascular Disease and Aging

1
Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU University, 1081HV Amsterdam, The Netherlands
2
Institute of Cardiovascular Regeneration, Goethe University, 60596 Frankfurt am Main, Germany
3
German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, 13347 Berlin, Germany
*
Author to whom correspondence should be addressed.
Non-Coding RNA 2019, 5(1), 26; https://doi.org/10.3390/ncrna5010026
Received: 15 February 2019 / Revised: 13 March 2019 / Accepted: 14 March 2019 / Published: 19 March 2019
(This article belongs to the Collection Regulatory RNAs in Cardiovascular Development and Disease)
Cardiovascular diseases are the most prominent cause of death in Western society, especially in the elderly. With the increasing life expectancy, the number of patients with cardiovascular diseases will rise in the near future, leading to an increased healthcare burden. There is a need for new therapies to treat this growing number of patients. The discovery of long non-coding RNAs has led to a novel group of molecules that could be considered for their potential as therapeutic targets. This review presents an overview of long non-coding RNAs that are regulated in vascular disease and aging and which might therefore give insight into new pathways that could be targeted to diagnose, prevent, and/or treat vascular diseases. View Full-Text
Keywords: aging; vascular disease; lncRNA aging; vascular disease; lncRNA
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Bink, D.I.; Lozano-Vidal, N.; Boon, R.A. Long Non-Coding RNA in Vascular Disease and Aging. Non-Coding RNA 2019, 5, 26.

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