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The Role of Long Non-Coding RNAs in Osteosarcoma

Department of Orthopaedics and Trauma, Medical University of Graz, Auenbruggerplatz 5, 8036 Graz, Austria
Division of Clinical Oncology, Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
Division of Cancer Medicine, MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA
Author to whom correspondence should be addressed.
Non-Coding RNA 2018, 4(1), 7;
Received: 15 February 2018 / Revised: 1 March 2018 / Accepted: 5 March 2018 / Published: 8 March 2018
PDF [203 KB, uploaded 8 March 2018]


Long non-coding RNAs (lncRNAs) constitute non-protein coding transcripts with a size > than 200 nucleotides. They are involved in many cellular processes, such as chromatin remodelling, transcription, and gene expression. They play a role in the development, progression, and invasion of many human cancers, including osteosarcoma. This rare tumor entity predominantly arises in children and young adults. Treatment consists of polychemotherapy and surgical resection, increasing survival rates up to 60%. In the present review, the role of lncRNAs with prognostic, predictive, therapeutic, and diagnostic significance in osteosarcoma is discussed. Moreover, their potential application in clinical practice is highlighted. View Full-Text
Keywords: lncRNA; osteosarcoma; pathogenesis lncRNA; osteosarcoma; pathogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Smolle, M.A.; Pichler, M. The Role of Long Non-Coding RNAs in Osteosarcoma. Non-Coding RNA 2018, 4, 7.

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