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Near-Wall Flow in Cerebral Aneurysms

1
Department of Mechanical Engineering, University of Bristol, Bristol BS8 1TH, UK
2
Departamento de Matemática and Centro de Matemática Computacional e Estocástica (CEMAT)/IST, Instituto Superior Técnico, University of Lisbon, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal
3
Department of Neurosurgery, Coimbra University Hospital Center, Faculty of Medicine, University of Coimbra, Rua Larga, 3004-504 Coimbra, Portugal
*
Author to whom correspondence should be addressed.
Fluids 2019, 4(2), 89; https://doi.org/10.3390/fluids4020089
Received: 16 March 2019 / Revised: 10 April 2019 / Accepted: 18 April 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Cardiovascular Flows)
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Abstract

The region where the vascular lumen meets the surrounding endothelium cell layer, hence the interface region between haemodynamics and cell tissue, is of primary importance in the physiological functions of the cardiovascular system. The functions include mass transport to/from the blood and tissue, and signalling via mechanotransduction, which are primary functions of the cardiovascular system and abnormalities in these functions are known to affect disease formation and vascular remodelling. This region is denoted by the near-wall region in the present work, and we outline simple yet effective numerical recipes to analyse the near-wall flow field. Computational haemodynamics solutions are presented for six patient specific cerebral aneurysms, at three instances in the cardiac cycle: peak systole, end systole (taken as dicrotic notch) and end diastole. A sensitivity study, based on Newtonian and non-Newtonian rheological models, and different flow rate profiles, is effected for a selection of aneurysm cases. The near-wall flow field is described by the wall shear stress (WSS) and the divergence of wall shear stress (WSSdiv), as descriptors of tangential and normal velocity components, respectively, as well as the wall shear stress critical points. Relations between near-wall and free-stream flow fields are discussed. View Full-Text
Keywords: cerebral aneurysm; computational haemodynamics; no-slip critical points; near-wall transport; description of flow field cerebral aneurysm; computational haemodynamics; no-slip critical points; near-wall transport; description of flow field
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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MDPI and ACS Style

Goodarzi Ardakani, V.; Tu, X.; Gambaruto, A.M.; Velho, I.; Tiago, J.; Sequeira, A.; Pereira, R. Near-Wall Flow in Cerebral Aneurysms. Fluids 2019, 4, 89.

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