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Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite

1
Chemical Engineering Department, Escola d’Enginyeria de Barcelona Est-EEBE, c/Eduard Maristany 10-14, 08019 Barcelona, Spain
2
Barcelona Research Center for Multiscale Science and Engineering, Universitat Politècnica de Catalunya, Escola d’Enginyeria de Barcelona Est-EEBE, c/Eduard Maristany 10-14, 08019 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
Received: 26 January 2019 / Revised: 19 February 2019 / Accepted: 25 February 2019 / Published: 6 March 2019
(This article belongs to the Special Issue Gels from the Self-Assembling of Peptide-Based Compounds)
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Abstract

Amphiphilic peptides can be self-assembled by establishing physical cross-links involving hydrogen bonds and electrostatic interactions with divalent ions. The derived hydrogels have promising properties due to their biocompatibility, reversibility, trigger capability, and tunability. Peptide hydrogels can mimic the extracellular matrix and favor the growth of hydroxyapatite (HAp) as well as its encapsulation. Newly designed materials offer great perspectives for applications in the regeneration of hard tissues such as bones, teeth, and cartilage. Furthermore, development of drug delivery systems based on HAp and peptide self-assembly is attracting attention. View Full-Text
Keywords: amphiphilic peptides; hydrogels; hydroxyapatite; tissue regeneration; bone; teeth; drug release amphiphilic peptides; hydrogels; hydroxyapatite; tissue regeneration; bone; teeth; drug release
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Rivas, M.; del Valle, L.J.; Alemán, C.; Puiggalí, J. Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite. Gels 2019, 5, 14.

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