Next Article in Journal
Stimuli-Responsive Gels
Previous Article in Journal
Hydrogels for Cell Delivery
Previous Article in Special Issue
Dynamic Behaviors of Solvent Molecules Restricted in Poly (Acryl Amide) Gels Analyzed by Dielectric and Diffusion NMR Spectroscopy
Article Menu
Issue 3 (September) cover image

Export Article

Open AccessArticle

Analysis of Heterogeneous Gelation Dynamics and Their Application to Blood Coagulation

1
Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma 376-8515, Japan
2
Division of Pure and Applied Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma 376-8515, Japan
*
Author to whom correspondence should be addressed.
Received: 11 May 2018 / Revised: 3 July 2018 / Accepted: 5 July 2018 / Published: 9 July 2018
Full-Text   |   PDF [2371 KB, uploaded 9 July 2018]   |  

Abstract

We present a scaling model based on a moving boundary picture to describe heterogeneous gelation dynamics. The dynamics of gelation induced by different gelation mechanisms is expressed by the scaled equation for the time taken for development of the gel layer with a few kinetic coefficients characterizing the system. The physical meaning obtained by the analysis for a simple boundary condition from the standpoint of the phase transition shows that the time development of the gelation layer depends on whether the dynamics of the order parameter expressing the gelation of the polymer solution is fast or slow compared with the diffusion of the gelators in the heterogeneous gelation. The analytical method is used to understand the coagulation of blood from various animals. An experiment using systems with plasma coagulation occurring at interfaces with calcium chloride solution and with packed erythrocytes is performed to provide the data for model fitting and it is clarified that a few key kinetic coefficients in plasma coagulation can be estimated from the analysis of gelation dynamics. View Full-Text
Keywords: heterogeneous gelation dynamics; moving boundary picture; phase transition dynamics; kinetic coefficient; blood coagulation heterogeneous gelation dynamics; moving boundary picture; phase transition dynamics; kinetic coefficient; blood coagulation
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Dobashi, T.; Yamamoto, T. Analysis of Heterogeneous Gelation Dynamics and Their Application to Blood Coagulation. Gels 2018, 4, 59.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Gels EISSN 2310-2861 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top