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Volume 10
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10.3390/gels10110699
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Article

Double Encapsulation of Resveratrol and Doxorubicin in Composite Nanogel—An Opportunity to Reduce Cardio- and Neurotoxicity of Doxorubicin

by
Lyubomira Radeva
1,*,
Yordan Yordanov
1,
Ivanka Spassova
2,
Daniela Kovacheva
2,
Virginia Tzankova
1 and
Krassimira Yoncheva
1,*
1
Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria
2
Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
*
Authors to whom correspondence should be addressed.
Gels 2024, 10(11), 699; https://doi.org/10.3390/gels10110699
Submission received: 23 September 2024 / Revised: 24 October 2024 / Accepted: 25 October 2024 / Published: 28 October 2024
(This article belongs to the Special Issue Hydrogels, Oleogels and Bigels Used for Drug Delivery)
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Abstract

The simultaneous encapsulation of drugs into nanosized delivery systems could be beneficial for cancer therapies since it could alleviate adverse reactions as well as provide synergistic effects. However, the encapsulation of hydrophobic drugs into hydrophilic nanoparticles, such as nanogels, could be challenging. Therefore, innovative technological approaches are needed. In this research, a composite nanogel system was prepared from chitosan, albumin, and hydroxypropyl-β-cyclodextrin for co-delivery of the hydrophilic anticancer drug doxorubicin and hydrophobic antioxidant resveratrol. The nanoparticles were characterized using dynamic light scattering and found to have a hydrodynamic diameter of approx. 31 nm, narrow size distribution (PDI = 0.188), positive ƺ-potential (+51.23 mV), and pH-dependent release of the loaded drugs. FTIR and X-ray analyses proved the successful development of the composite nanogel. Moreover, the double-loaded system showed that the loading of resveratrol exerted protection against doxorubicin-induced toxicity in cardioblast H9c2 and neuroblast SH-SY5Y cells. The simultaneous loading did not influence the cytostatic effect of the antitumor agent in lymphoma L5178Y and L5178MDR cell lines.
Keywords: composite nanogel; resveratrol; doxorubicin; chitosan; albumin; hydroxypropyl-β-cyclodextrin; cardiotoxicity; neurotoxicity composite nanogel; resveratrol; doxorubicin; chitosan; albumin; hydroxypropyl-β-cyclodextrin; cardiotoxicity; neurotoxicity
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MDPI and ACS Style

Radeva, L.; Yordanov, Y.; Spassova, I.; Kovacheva, D.; Tzankova, V.; Yoncheva, K. Double Encapsulation of Resveratrol and Doxorubicin in Composite Nanogel—An Opportunity to Reduce Cardio- and Neurotoxicity of Doxorubicin. Gels 2024, 10, 699. https://doi.org/10.3390/gels10110699

AMA Style

Radeva L, Yordanov Y, Spassova I, Kovacheva D, Tzankova V, Yoncheva K. Double Encapsulation of Resveratrol and Doxorubicin in Composite Nanogel—An Opportunity to Reduce Cardio- and Neurotoxicity of Doxorubicin. Gels. 2024; 10(11):699. https://doi.org/10.3390/gels10110699

Chicago/Turabian Style

Radeva, Lyubomira, Yordan Yordanov, Ivanka Spassova, Daniela Kovacheva, Virginia Tzankova, and Krassimira Yoncheva. 2024. "Double Encapsulation of Resveratrol and Doxorubicin in Composite Nanogel—An Opportunity to Reduce Cardio- and Neurotoxicity of Doxorubicin" Gels 10, no. 11: 699. https://doi.org/10.3390/gels10110699

APA Style

Radeva, L., Yordanov, Y., Spassova, I., Kovacheva, D., Tzankova, V., & Yoncheva, K. (2024). Double Encapsulation of Resveratrol and Doxorubicin in Composite Nanogel—An Opportunity to Reduce Cardio- and Neurotoxicity of Doxorubicin. Gels, 10(11), 699. https://doi.org/10.3390/gels10110699

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