A Phylogeographic Description of Histoplasma capsulatum in the United States
Abstract
:1. Introduction
2. Materials and Methods
2.1. Culture and DNA Extraction
2.2. Genomic Sequencing
2.3. Single-Nucleotide Polymorphism (SNP) and Phylogenetic Analysis
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Count | Percentage (%) | |
---|---|---|
Sex | ||
Male | 39 | 81 |
Female | 9 | 19 |
Total | 48 | 100 |
Age Group | ||
<21 | 6 | 13 |
≥21 & <65 | 25 | 52 |
≥65 | 17 | 35 |
Total | 48 | 100 |
Immunosuppressed cases | ||
Indiana | 1 | 5 |
Kentucky | 3 | 16 |
Michigan | 6 | 32 |
Minnesota | 8 | 42 |
Wisconsin | 1 | 5 |
Total | 19 | 100 |
Specimen Source | ||
Sputum | 4 | 8 |
Lymph node | 4 | 8 |
Bronchial specimen | 17 | 35 |
Lung tissue | 3 | 6 |
Blood | 12 | 25 |
Bone marrow | 3 | 6 |
Others * | 5 | 10 |
Total | 48 | 100 |
States | ||
Indiana | 2 | 4 |
Kentucky | 4 | 8 |
Louisiana | 1 | 2 |
Michigan | 21 | 44 |
Minnesota | 13 | 27 |
Nebraska | 1 | 2 |
Pennsylvania | 1 | 2 |
Wisconsin | 5 | 10 |
Total | 48 | 100 |
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Bagal, U.R.; Gade, L.; Benedict, K.; Howell, V.; Christophe, N.; Gibbons-Burgener, S.; Hallyburton, S.; Ireland, M.; McCracken, S.; Metobo, A.K.; et al. A Phylogeographic Description of Histoplasma capsulatum in the United States. J. Fungi 2023, 9, 884. https://doi.org/10.3390/jof9090884
Bagal UR, Gade L, Benedict K, Howell V, Christophe N, Gibbons-Burgener S, Hallyburton S, Ireland M, McCracken S, Metobo AK, et al. A Phylogeographic Description of Histoplasma capsulatum in the United States. Journal of Fungi. 2023; 9(9):884. https://doi.org/10.3390/jof9090884
Chicago/Turabian StyleBagal, Ujwal R., Lalitha Gade, Kaitlin Benedict, Victoria Howell, Natalie Christophe, Suzanne Gibbons-Burgener, Sara Hallyburton, Malia Ireland, Stephanie McCracken, Alison Keyser Metobo, and et al. 2023. "A Phylogeographic Description of Histoplasma capsulatum in the United States" Journal of Fungi 9, no. 9: 884. https://doi.org/10.3390/jof9090884