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Review

Guanidine-Containing Antifungal Agents against Human-Relevant Fungal Pathogens (2004–2022)—A Review

by
Simon D. P. Baugh
Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902, USA
J. Fungi 2022, 8(10), 1085; https://doi.org/10.3390/jof8101085
Submission received: 20 September 2022 / Revised: 10 October 2022 / Accepted: 13 October 2022 / Published: 15 October 2022
(This article belongs to the Special Issue Antifungal Drug Discovery: Novel Therapies and Approaches)
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Abstract

The guanidine moiety is typically a highly basic group, and can be found in a wide variety of drugs, such as zanamivir (Relenza) and metformin (Fortamet), as well as in biologically active compounds for numerous disease areas, including central nervous system (CNS) diseases and chemotherapeutics. This review will focus on antifungal agents which contain at least one guanidine group, for the treatment of human-related fungal pathogens, described in the literature between 2004 and 2022. These compounds include small molecules, steroids, polymers, metal complexes, sesquiterpenes, natural products, and polypeptides. It shall be made clear that a diverse range of guanidine-containing derivatives have been published in the literature and have antifungal activity, including efficacy in in vivo experiments.
Keywords: antifungal agent; guanidine; small molecule; steroid; polymer; metal complex; sesquiterpene; natural product; polypeptide antifungal agent; guanidine; small molecule; steroid; polymer; metal complex; sesquiterpene; natural product; polypeptide

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MDPI and ACS Style

Baugh, S.D.P. Guanidine-Containing Antifungal Agents against Human-Relevant Fungal Pathogens (2004–2022)—A Review. J. Fungi 2022, 8, 1085. https://doi.org/10.3390/jof8101085

AMA Style

Baugh SDP. Guanidine-Containing Antifungal Agents against Human-Relevant Fungal Pathogens (2004–2022)—A Review. Journal of Fungi. 2022; 8(10):1085. https://doi.org/10.3390/jof8101085

Chicago/Turabian Style

Baugh, Simon D. P. 2022. "Guanidine-Containing Antifungal Agents against Human-Relevant Fungal Pathogens (2004–2022)—A Review" Journal of Fungi 8, no. 10: 1085. https://doi.org/10.3390/jof8101085

APA Style

Baugh, S. D. P. (2022). Guanidine-Containing Antifungal Agents against Human-Relevant Fungal Pathogens (2004–2022)—A Review. Journal of Fungi, 8(10), 1085. https://doi.org/10.3390/jof8101085

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