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Review

Tools for Assessing Translation in Cryptococcus neoformans

by
Corey M. Knowles
,
Kelcy M. McIntyre
and
John C. Panepinto
*
Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14201, USA
*
Author to whom correspondence should be addressed.
J. Fungi 2021, 7(3), 159; https://doi.org/10.3390/jof7030159
Submission received: 27 January 2021 / Revised: 17 February 2021 / Accepted: 20 February 2021 / Published: 24 February 2021
(This article belongs to the Special Issue Molecular and Genetic Tools for Studying Cryptococcus spp.)
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Abstract

Cryptococcus neoformans is a ubiquitous environmental fungus capable of establishing an infection in a human host. Rapid changes in environments and exposure to the host immune system results in a significant amount of cellular stress, which is effectively combated at the level of translatome reprogramming. Repression of translation following stress allows for the specific reallocation of limited resources. Understanding the mechanisms involved in regulating translation in C. neoformans during host infection is critical in the development of new antifungal drugs. In this review, we discuss the main tools available for assessing changes in translation state and translational output during cellular stress.
Keywords: translation; initiation; elongation; repression; translation regulation; host adaptation translation; initiation; elongation; repression; translation regulation; host adaptation

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MDPI and ACS Style

Knowles, C.M.; McIntyre, K.M.; Panepinto, J.C. Tools for Assessing Translation in Cryptococcus neoformans. J. Fungi 2021, 7, 159. https://doi.org/10.3390/jof7030159

AMA Style

Knowles CM, McIntyre KM, Panepinto JC. Tools for Assessing Translation in Cryptococcus neoformans. Journal of Fungi. 2021; 7(3):159. https://doi.org/10.3390/jof7030159

Chicago/Turabian Style

Knowles, Corey M., Kelcy M. McIntyre, and John C. Panepinto. 2021. "Tools for Assessing Translation in Cryptococcus neoformans" Journal of Fungi 7, no. 3: 159. https://doi.org/10.3390/jof7030159

APA Style

Knowles, C. M., McIntyre, K. M., & Panepinto, J. C. (2021). Tools for Assessing Translation in Cryptococcus neoformans. Journal of Fungi, 7(3), 159. https://doi.org/10.3390/jof7030159

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