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Open AccessReview

Nikkomycin Z—Ready to Meet the Promise?

by 1,2,3
1
Valley Fever Solutions, Tucson, AZ 85719, USA
2
College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
3
California Institute of Medical Research, San Jose, CA 95128, USA
J. Fungi 2020, 6(4), 261; https://doi.org/10.3390/jof6040261
Received: 22 September 2020 / Revised: 19 October 2020 / Accepted: 22 October 2020 / Published: 30 October 2020
(This article belongs to the Special Issue Antifungal Agents Recently Approved or Under Development)
Nikkomycin Z (NikZ) has fungicidal activity against some fungal species which currently requires patients to endure chronic therapy, sometimes for years. This review highlights reports of NikZ activity against fungal species for which current therapeutics are still inadequate, as a potential roadmap for continuing investigation. The possibility of faster and more complete clinical resolution by using NikZ has attracted scientific attention for decades. NikZ inhibits chitin structure formation, which is important for fungi, but not found in mammals. NikZ raised no safety concerns in a human Phase 1 trial or in extensive toxicology studies. NikZ showed strong clinical benefit in dogs with natural Coccidioides infection. NikZ has protected animals against fatal infections of Candida albicans. NikZ provides high protection in synergistic combination with several agent classes against Candida and Aspergillus species. View Full-Text
Keywords: antifungal; nikkomycin Z; NikZ; combination therapy; endemic dimorphic fungi; opportunistic fungi; Coccidioides spp.; Candida albicans; Aspergillus fumigatus antifungal; nikkomycin Z; NikZ; combination therapy; endemic dimorphic fungi; opportunistic fungi; Coccidioides spp.; Candida albicans; Aspergillus fumigatus
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MDPI and ACS Style

Larwood, D.J. Nikkomycin Z—Ready to Meet the Promise? J. Fungi 2020, 6, 261. https://doi.org/10.3390/jof6040261

AMA Style

Larwood DJ. Nikkomycin Z—Ready to Meet the Promise? Journal of Fungi. 2020; 6(4):261. https://doi.org/10.3390/jof6040261

Chicago/Turabian Style

Larwood, David J. 2020. "Nikkomycin Z—Ready to Meet the Promise?" J. Fungi 6, no. 4: 261. https://doi.org/10.3390/jof6040261

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