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Novel Antifungal Agents and Their Activity against Aspergillus Species

Institute of Hygiene and Medical Microbiology, Medical University Innsbruck, 6020 Innsbruck, Austria
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J. Fungi 2020, 6(4), 213; https://doi.org/10.3390/jof6040213
Received: 8 September 2020 / Revised: 30 September 2020 / Accepted: 7 October 2020 / Published: 9 October 2020
(This article belongs to the Special Issue Aspergillus Infection)
There is a need for new antifungal agents, mainly due to increased incidence of invasive fungal infections (IFI), high frequency of associated morbidity and mortality and limitations of the current antifungal agents (e.g., toxicity, drug–drug interactions, and resistance). The clinically available antifungals for IFI are restricted to four main classes: polyenes, flucytosine, triazoles, and echinocandins. Several antifungals are hampered by multiple resistance mechanisms being present in fungi. Consequently, novel antifungal agents with new targets and modified chemical structures are required to combat fungal infections. This review will describe novel antifungals, with a focus on the Aspergillus species. View Full-Text
Keywords: novel antifungal drugs; new therapies; invasive fungal infections; aspergillosis novel antifungal drugs; new therapies; invasive fungal infections; aspergillosis
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Vahedi-Shahandashti, R.; Lass-Flörl, C. Novel Antifungal Agents and Their Activity against Aspergillus Species. J. Fungi 2020, 6, 213.

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