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The Squeaky Yeast Gets Greased: The Roles of Host Lipids in the Clearance of Pathogenic Fungi

1
Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA
2
Biology & Chemistry Department, University of Osnabrück, Fachbereich Biologie/Chemie, Barbarastrasse 13, 49076 Osnabrück, Germany
*
Author to whom correspondence should be addressed.
J. Fungi 2020, 6(1), 19; https://doi.org/10.3390/jof6010019
Received: 30 December 2019 / Revised: 21 January 2020 / Accepted: 26 January 2020 / Published: 31 January 2020
(This article belongs to the Special Issue Lipids and Fungal Infectious Diseases)
Fungal infections remain a global health threat with high morbidity and mortality. The human immune system must, therefore, perpetually defend against invasive fungal infections. Phagocytosis is critical for the clearance of fungal pathogens, as this cellular process allows select immune cells to internalize and destroy invading fungal cells. While much is known about the protein players that enable phagocytosis, the various roles that lipids play during this fundamental innate immune process are still being illuminated. In this review, we describe recent discoveries that shed new light on the mechanisms by which host lipids enable the phagocytic uptake and clearance of fungal pathogens.
Keywords: phagocytosis; phagolysosomal maturation; fungal pathogens; sphingolipids; phosphoniositides phagocytosis; phagolysosomal maturation; fungal pathogens; sphingolipids; phosphoniositides
MDPI and ACS Style

Guzman, G.; Niekamp, P.; Tafesse, F.G. The Squeaky Yeast Gets Greased: The Roles of Host Lipids in the Clearance of Pathogenic Fungi. J. Fungi 2020, 6, 19.

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