Next Article in Journal
The Squeaky Yeast Gets Greased: The Roles of Host Lipids in the Clearance of Pathogenic Fungi
Next Article in Special Issue
An Overview on Conventional and Non-Conventional Therapeutic Approaches for the Treatment of Candidiasis and Underlying Resistance Mechanisms in Clinical Strains
Previous Article in Journal
Acknowledgement to Reviewers of Journal of Fungi in 2019
Previous Article in Special Issue
Detecting Azole-Antifungal Resistance in Aspergillus fumigatus by Pyrosequencing
Open AccessReview

Blood Aspergillus PCR: The Good, the Bad, and the Ugly

by Matthias Egger 1, Jeffrey D. Jenks 2,3,†, Martin Hoenigl 1,2,3,† and Juergen Prattes 1,*,†
Section of Infectious Diseases and Tropical Medicine, Medical University of Graz, 8036 Graz, Austria
Department of Medicine, University of California San Diego, San Diego, 92093 CA, USA
Clinical and Translational Fungal Research Group, University of California Sand Diego, San Diego, CA 92093, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Fungi 2020, 6(1), 18;
Received: 29 December 2019 / Revised: 17 January 2020 / Accepted: 20 January 2020 / Published: 27 January 2020
(This article belongs to the Special Issue Molecular Diagnostics of Fungal Infections)
Invasive Aspergillosis (IA) is one of the most common invasive fungal diseases and is accompanied by high morbidity and mortality. In order to maximize patient outcomes and survival, early and rapid diagnosis has been shown to be pivotal. Hence, diagnostic tools aiding and improving the diagnostic process are ambitiously searched for. In this context, polymerase chain reaction (PCR) may represent a potential candidate. Its additional value and benefits in diagnosis have been demonstrated and are scientifically established. Nevertheless, standardized and widespread usage is sparse because several factors influence diagnostic quality and need to be considered in order to optimize diagnostic performance and outcome. In the following review, the current role of PCR in the diagnosis of IA is explored, with special focus on the strengths and limitations of PCR in different settings.
Keywords: Aspergillus; invasive aspergillosis; diagnosis; PCR; blood; antifungal prophylaxis Aspergillus; invasive aspergillosis; diagnosis; PCR; blood; antifungal prophylaxis
MDPI and ACS Style

Egger, M.; Jenks, J.D.; Hoenigl, M.; Prattes, J. Blood Aspergillus PCR: The Good, the Bad, and the Ugly. J. Fungi 2020, 6, 18.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop