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Blood Aspergillus PCR: The Good, the Bad, and the Ugly

by Matthias Egger 1, Jeffrey D. Jenks 2,3,†, Martin Hoenigl 1,2,3,† and Juergen Prattes 1,*,†
1
Section of Infectious Diseases and Tropical Medicine, Medical University of Graz, 8036 Graz, Austria
2
Department of Medicine, University of California San Diego, San Diego, 92093 CA, USA
3
Clinical and Translational Fungal Research Group, University of California Sand Diego, San Diego, CA 92093, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Fungi 2020, 6(1), 18; https://doi.org/10.3390/jof6010018
Received: 29 December 2019 / Revised: 17 January 2020 / Accepted: 20 January 2020 / Published: 27 January 2020
(This article belongs to the Special Issue Molecular Diagnostics of Fungal Infections)
Invasive Aspergillosis (IA) is one of the most common invasive fungal diseases and is accompanied by high morbidity and mortality. In order to maximize patient outcomes and survival, early and rapid diagnosis has been shown to be pivotal. Hence, diagnostic tools aiding and improving the diagnostic process are ambitiously searched for. In this context, polymerase chain reaction (PCR) may represent a potential candidate. Its additional value and benefits in diagnosis have been demonstrated and are scientifically established. Nevertheless, standardized and widespread usage is sparse because several factors influence diagnostic quality and need to be considered in order to optimize diagnostic performance and outcome. In the following review, the current role of PCR in the diagnosis of IA is explored, with special focus on the strengths and limitations of PCR in different settings.
Keywords: Aspergillus; invasive aspergillosis; diagnosis; PCR; blood; antifungal prophylaxis Aspergillus; invasive aspergillosis; diagnosis; PCR; blood; antifungal prophylaxis
MDPI and ACS Style

Egger, M.; Jenks, J.D.; Hoenigl, M.; Prattes, J. Blood Aspergillus PCR: The Good, the Bad, and the Ugly. J. Fungi 2020, 6, 18.

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