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On the Origins of a Species: What Might Explain the Rise of Candida auris?
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Molecular Diagnostics in the Times of Surveillance for Candida auris

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA
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J. Fungi 2019, 5(3), 77; https://doi.org/10.3390/jof5030077
Received: 27 July 2019 / Revised: 15 August 2019 / Accepted: 17 August 2019 / Published: 20 August 2019
(This article belongs to the Special Issue Candida auris)
Recently, global health professionals have been significantly challenged by the emergence of Candida auris and its propensity to colonize human skin, persist in the healthcare environment, and cause healthcare-associated outbreaks. Additionally, C. auris isolates are often characterized by elevated minimal inhibitory concentration (MIC) values for antifungal drugs. Thus, rapid detection and accurate identification of C. auris together with an assessment of potential antifungal drug resistance has become essential for effective patient management, and infection prevention and control in healthcare facilities. Surprisingly, almost all of the commonly available diagnostic tools rely on recovery (growth) of yeast colonies from collected samples, which delays the diagnostic result by several days or longer. To circumvent these issues, molecular-based DNA amplification assays have been developed to identify C. auris DNA directly from patient samples. Moreover, allele discriminating detection probes can be used to rapidly assess validated mechanisms of echinocandin and azole resistance. View Full-Text
Keywords: Candida auris; diagnostics; molecular diagnostics; identification; detection; antifungal drug resistance; azoles; echinocandins Candida auris; diagnostics; molecular diagnostics; identification; detection; antifungal drug resistance; azoles; echinocandins
MDPI and ACS Style

Kordalewska, M.; Perlin, D.S. Molecular Diagnostics in the Times of Surveillance for Candida auris. J. Fungi 2019, 5, 77.

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