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Mucormycosis of the Central Nervous System

Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
Department of Infectious Diseases, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA
Authors to whom correspondence should be addressed.
These authors contribute equally to this paper.
J. Fungi 2019, 5(3), 59;
Received: 6 June 2019 / Revised: 5 July 2019 / Accepted: 7 July 2019 / Published: 8 July 2019
(This article belongs to the Special Issue Fungal Infections of the Central Nervous System)
Mucormycosis involves the central nervous system by direct extension from infected paranasal sinuses or hematogenous dissemination from the lungs. Incidence rates of this rare disease seem to be rising, with a shift from the rhino-orbital-cerebral syndrome typical of patients with diabetes mellitus and ketoacidosis, to disseminated disease in patients with hematological malignancies. We present our current understanding of the pathobiology, clinical features, and diagnostic and treatment strategies of cerebral mucormycosis. Despite advances in imaging and the availability of novel drugs, cerebral mucormycosis continues to be associated with high rates of death and disability. Emerging molecular diagnostics, advances in experimental systems and the establishment of large patient registries are key components of ongoing efforts to provide a timely diagnosis and effective treatment to patients with cerebral mucormycosis. View Full-Text
Keywords: central nervous system; mucormycosis; Mucorales; zygomycosis central nervous system; mucormycosis; Mucorales; zygomycosis
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MDPI and ACS Style

Chikley, A.; Ben-Ami, R.; Kontoyiannis, D.P. Mucormycosis of the Central Nervous System. J. Fungi 2019, 5, 59.

AMA Style

Chikley A, Ben-Ami R, Kontoyiannis DP. Mucormycosis of the Central Nervous System. Journal of Fungi. 2019; 5(3):59.

Chicago/Turabian Style

Chikley, Amanda; Ben-Ami, Ronen; Kontoyiannis, Dimitrios P 2019. "Mucormycosis of the Central Nervous System" J. Fungi 5, no. 3: 59.

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