Central Nervous System Infections Due to Coccidioidomycosis
Abstract
1. Introduction
2. Epidemiology and Risk Factors
3. Pathogenesis
4. Clinical Presentation
5. Diagnosis
6. Treatment
7. Complications
8. Summary
Funding
Conflicts of Interest
References
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Antifungal Agent | Typical Dose/Frequency | Notes | Comments |
---|---|---|---|
First-line treatment | |||
Fluconazole | 400–800 mg orally daily | • absorbed well orally | • dosing to 1200 mg/daily can be considered if patient has a clinically inadequate response |
Alternatives to first-line agent | |||
Itraconazole | 200 mg orally BID–TID |
|
|
For failures of initial therapy | |||
Voriconazole | 200–400 mg orally BID |
|
|
Posaconazole | 300 mg daily as delayed-release (DR) preparation |
|
|
Rescue therapy for azole-intolerant infection | |||
IT amphotericin B deoxycholate (AMBd) |
|
|
|
Less well established adjunctive therapy | |||
Dexamethasone | 20 mg daily × 7 days, then lower dose by 4 mg every other day | • may be useful in cases of vasculitis |
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Jackson, N.R.; Blair, J.E.; Ampel, N.M. Central Nervous System Infections Due to Coccidioidomycosis. J. Fungi 2019, 5, 54. https://doi.org/10.3390/jof5030054
Jackson NR, Blair JE, Ampel NM. Central Nervous System Infections Due to Coccidioidomycosis. Journal of Fungi. 2019; 5(3):54. https://doi.org/10.3390/jof5030054
Chicago/Turabian StyleJackson, Niki R., Janis E. Blair, and Neil M. Ampel. 2019. "Central Nervous System Infections Due to Coccidioidomycosis" Journal of Fungi 5, no. 3: 54. https://doi.org/10.3390/jof5030054
APA StyleJackson, N. R., Blair, J. E., & Ampel, N. M. (2019). Central Nervous System Infections Due to Coccidioidomycosis. Journal of Fungi, 5(3), 54. https://doi.org/10.3390/jof5030054