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The Spectrum of Interactions between Cryptococcus neoformans and Bacteria

1
Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
2
Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
*
Author to whom correspondence should be addressed.
J. Fungi 2019, 5(2), 31; https://doi.org/10.3390/jof5020031
Received: 27 March 2019 / Revised: 8 April 2019 / Accepted: 11 April 2019 / Published: 12 April 2019
Cryptococcus neoformans is a major fungal pathogen that infects immunocompromised people and causes life-threatening meningoencephalitis. C. neoformans does not occur in isolation either in the environment or in the human host, but is surrounded by other microorganisms. Bacteria are ubiquitously distributed in nature, including soil, and make up the dominant part of the human microbiota. Pioneering studies in the 1950s demonstrated antifungal activity of environmental bacteria against C. neoformans. However, the mechanisms and implications of these interactions remain largely unknown. Recently, interest in polymicrobial interaction studies has been reignited by the development of improved sequencing methodologies, and by the realization that such interactions may have a huge impact on ecology and human health. In this review, we summarize our current understanding of the interaction of bacteria with C. neoformans. View Full-Text
Keywords: Cryptococcus; fungal pathogen; bacteria; interkingdom-interactions; antifungal activity Cryptococcus; fungal pathogen; bacteria; interkingdom-interactions; antifungal activity
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Mayer, F.L.; Kronstad, J.W. The Spectrum of Interactions between Cryptococcus neoformans and Bacteria. J. Fungi 2019, 5, 31.

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