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J. Fungi 2019, 5(1), 23;

Disease Entities in Mucormycosis

Université Paris Descartes, Centre d’Infectiologie Necker Pasteur, IHU Imagine, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), 75015 Paris, France
Centre National de Référence mycoses invasives et antifongiques, Unité de Mycologie Moléculaire, Institut Pasteur, 75015 Paris, France
Author to whom correspondence should be addressed.
Received: 29 January 2019 / Revised: 9 March 2019 / Accepted: 11 March 2019 / Published: 14 March 2019
(This article belongs to the Special Issue Mucorales and Mucormycosis)
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Mucormycosis is an emerging life-threatening fungal infection caused by Mucorales. This infection occurs mainly in immunocompromised patients, especially with hematological malignancy, transplantation, or diabetes mellitus. Rhino-orbito-cerebral and pulmonary mucormycosis are the predominant forms. Interestingly, location is associated with the underlying disease as pulmonary mucormycosis is more frequent in hematological malignancy patients whereas rhino-orbito-cerebral mucormycosis is associated with diabetes. Cutaneous mucormycosis results from direct inoculation, mainly after trauma or surgery. Gastro-intestinal mucormycosis occurs after ingestion of contaminated food or with contaminated device and involves the stomach or colon. Disseminated disease is the most severe form and is associated with profound immunosuppression. Uncommon presentations with endocarditis, osteoarticluar or isolated cerebral infections are also described. Finally, health-care associated mucormycosis is a matter of concern in premature newborns and burn units. Clinical symptoms and CT scan findings are not specific, only the early reversed halo sign is associated with pulmonary mucormycosis. Circulating Mucorales DNA detection is a recent promising diagnostic tool that may lead to improving the diagnosis and prompting therapeutic initiation that should include antifungal treatment, correction of the underlying disease and surgery when feasible. View Full-Text
Keywords: Mucormycosis; Mucorales; rhino-orbito-cerebral mucormycosis; pulmonary mucormycosis; health-care Mucormycosis; Mucorales; rhino-orbito-cerebral mucormycosis; pulmonary mucormycosis; health-care

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Serris, A.; Danion, F.; Lanternier, F. Disease Entities in Mucormycosis. J. Fungi 2019, 5, 23.

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