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J. Fungi 2019, 5(1), 18; https://doi.org/10.3390/jof5010018

Chronic Pulmonary Aspergillosis in Patients with Underlying Respiratory Disorders in Cuba—A Pilot Study

1
Benéfico-Jurídico Pneumological Hospital, 10600 Havana, Cuba
2
Pedro Kourí Institute of Tropical Medicine, 17100 Havana, Cuba
*
Author to whom correspondence should be addressed.
Received: 13 December 2018 / Revised: 14 February 2019 / Accepted: 15 February 2019 / Published: 22 February 2019
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Abstract

Chronic pulmonary aspergillosis (CPA) is a fungal infection with high mortality and morbidity rates. This disease is caused by several Aspergillus species and affects patients with an underlying respiratory condition. This pilot study aims to recognize CPA among patients with different respiratory diseases. Twenty-one out of 47 patients were classified as CPA based on the examination of clinical signs and symptoms, radiological findings, mycological culture of respiratory samples and analysis of Aspergillus IgG antibodies. There was a close association between high levels of Aspergillus IgG antibodies and the presence of cavities. Although Aspergillus flavus was the predominant species among clinical isolates, the number of isolates was small to reach conclusions on the prevalence of this species as main cause of CPA in Cuba. From the eleven evaluable patients for the treatment with itraconazole (Lozartil®), nine improved their health status while two did not show any recovery. This drug is included in the therapy schemes for aspergillosis in Cuba. View Full-Text
Keywords: aspergillosis; diagnosis; cavities; IgG; itraconazole aspergillosis; diagnosis; cavities; IgG; itraconazole
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Beltrán Rodríguez, N.; San Juan-Galán, J.L.; Fernández Andreu, C.M.; María Yera, D.; Barrios Pita, M.; Perurena Lancha, M.R.; Velar Martínez, R.E.; Illnait Zaragozí, M.T.; Martínez Machín, G.F. Chronic Pulmonary Aspergillosis in Patients with Underlying Respiratory Disorders in Cuba—A Pilot Study. J. Fungi 2019, 5, 18.

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