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J. Fungi 2018, 4(4), 141; https://doi.org/10.3390/jof4040141

Development and Applications of Prognostic Risk Models in the Management of Invasive Mold Disease

1
Institute of Hematology “Lorenzo e Ariosto Seràgnoli”, Department of Hematology and Clinical Oncology, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
2
Clinic of Infectious Diseases, Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
*
Author to whom correspondence should be addressed.
Received: 16 November 2018 / Revised: 10 December 2018 / Accepted: 14 December 2018 / Published: 19 December 2018
(This article belongs to the Special Issue Fungal Infections in Immunocompromised Hosts)
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Abstract

Prognostic models or risk scores are frequently used to aid individualize risk assessment for diseases with multiple, complex risk factors and diagnostic challenges. However, relatively little attention has been paid to the development of risk models for invasive mold diseases encountered in patients with hematological malignancies, despite a large body of epidemiological research. Herein we review recent studies that have described the development of prognostic models for mold disease, summarize our experience with the development and clinical use of one such model (BOSCORE), and discuss the potential impact of prognostic risk scores for individualized therapy, diagnostic and antifungal stewardship, as well as clinical and epidemiological research. View Full-Text
Keywords: prognostic risk model; prediction models; risk score; invasive mold disease; hematological malignancy; risk assessment; antifungal stewardship prognostic risk model; prediction models; risk score; invasive mold disease; hematological malignancy; risk assessment; antifungal stewardship
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Stanzani, M.; Lewis, R.E. Development and Applications of Prognostic Risk Models in the Management of Invasive Mold Disease. J. Fungi 2018, 4, 141.

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