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J. Fungi 2018, 4(4), 140; https://doi.org/10.3390/jof4040140

The Significance of Lipids to Biofilm Formation in Candida albicans: An Emerging Perspective

Yeast Molecular Genetics Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
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Received: 28 November 2018 / Revised: 13 December 2018 / Accepted: 15 December 2018 / Published: 18 December 2018
(This article belongs to the Special Issue Cell Adhesion in Fungal Life and Pathogenesis)
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Abstract

Candida albicans, the dimorphic opportunistic human fungal pathogen, is capable of forming highly drug-resistant biofilms in the human host. Formation of biofilm is a multistep and multiregulatory process involving various adaptive mechanisms. The ability of cells in a biofilm to alter membrane lipid composition is one such adaptation crucial for biofilm development in C. albicans. Lipids modulate mixed species biofilm formation in vivo and inherent antifungal resistance associated with these organized communities. Cells in C. albicans biofilms display phase-dependent changes in phospholipid classes and in levels of lipid raft formation. Systematic studies with genetically modified strains in which the membrane phospholipid composition can be manipulated are limited in C. albicans. In this review, we summarize the knowledge accumulated on the impact that alterations in phospholipids may have on the biofilm forming ability of C. albicans in the human host. This review may provide the requisite impetus to analyze lipids from a therapeutic standpoint in managing C. albicans biofilms. View Full-Text
Keywords: Candida albicans; biofilm; lipids; extracellular matrix; drug resistance; antifungal therapy; flippase; mixed-species biofilm; plasma membrane; transcription factors Candida albicans; biofilm; lipids; extracellular matrix; drug resistance; antifungal therapy; flippase; mixed-species biofilm; plasma membrane; transcription factors
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Alim, D.; Sircaik, S.; Panwar, S.L. The Significance of Lipids to Biofilm Formation in Candida albicans: An Emerging Perspective. J. Fungi 2018, 4, 140.

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