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Going with the Flo: The Role of Flo11-Dependent and Independent Interactions in Yeast Mat Formation

Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
J. Fungi 2018, 4(4), 132; https://doi.org/10.3390/jof4040132
Received: 10 October 2018 / Revised: 23 November 2018 / Accepted: 29 November 2018 / Published: 7 December 2018
(This article belongs to the Special Issue Cell Adhesion in Fungal Life and Pathogenesis)
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Abstract

Strains of the bakers’ yeast Saccharomyces cerevisiae that are able to generate a multicellular structure called a mat on low percentage (0.3%) agar plates are given a selective advantage over strains that cannot exhibit this phenotype. This environment may exhibit some similarities to the rotting fruit on which S. cerevisiae often grows in nature. Mat formation occurs when the cells spread over the plate as they grow, and cells in the center of the biofilm aggregate to form multicellular structures that resemble a floral pattern. This multicellular behavior is dependent on the cell surface flocculin Flo11. This review covers recent information on the structure of Flo11 and how this likely impacts mat formation as well as how variegated expression of Flo11 influences mat formation. Finally, it also discusses several Flo11-independent genetic factors that control mat formation, such as vacuolar protein sorting (VPS) genes, cell wall signaling components, and heat shock proteins. View Full-Text
Keywords: Flo11; biofilm; mat formation; flocculins; adhesins Flo11; biofilm; mat formation; flocculins; adhesins
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Reynolds, T.B. Going with the Flo: The Role of Flo11-Dependent and Independent Interactions in Yeast Mat Formation. J. Fungi 2018, 4, 132.

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