Next Article in Journal
Antifungal Resistance: Specific Focus on Multidrug Resistance in Candida auris and Secondary Azole Resistance in Aspergillus fumigatus
Next Article in Special Issue
Anti-Candida albicans Activity of Thiazolylhydrazone Derivatives in Invertebrate and Murine Models
Previous Article in Journal
Therapy and Management of Pneumocystis jirovecii Infection
Previous Article in Special Issue
An Invertebrate Host to Study Fungal Infections, Mycotoxins and Antifungal Drugs: Tenebrio molitor
Article Menu
Issue 4 (December) cover image

Export Article

Open AccessReview
J. Fungi 2018, 4(4), 128; https://doi.org/10.3390/jof4040128

Recent Advances in the Use of Galleria mellonella Model to Study Immune Responses against Human Pathogens

Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, São Paulo 12245-000, Brazil
*
Author to whom correspondence should be addressed.
Received: 31 October 2018 / Revised: 21 November 2018 / Accepted: 26 November 2018 / Published: 27 November 2018
(This article belongs to the Special Issue Alternative Models for the Study of Fungal Host-Pathogen Interactions)
Full-Text   |   PDF [1296 KB, uploaded 5 December 2018]   |  

Abstract

The use of invertebrates for in vivo studies in microbiology is well established in the scientific community. Larvae of Galleria mellonella are a widely used model for studying pathogenesis, the efficacy of new antimicrobial compounds, and immune responses. The immune system of G. mellonella larvae is structurally and functionally similar to the innate immune response of mammals, which makes this model suitable for such studies. In this review, cellular responses (hemocytes activity: phagocytosis, nodulation, and encapsulation) and humoral responses (reactions or soluble molecules released in the hemolymph as antimicrobial peptides, melanization, clotting, free radical production, and primary immunization) are discussed, highlighting the use of G. mellonella as a model of immune response to different human pathogenic microorganisms. View Full-Text
Keywords: Galleria mellonella; in vivo study; experimental model; hemocytes; immune response; melanization; antimicrobial peptides; clotting; free radical production; primary immunization Galleria mellonella; in vivo study; experimental model; hemocytes; immune response; melanization; antimicrobial peptides; clotting; free radical production; primary immunization
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Pereira, T.C.; de Barros, P.P.; Fugisaki, L.R.O.; Rossoni, R.D.; Ribeiro, F.C.; de Menezes, R.T.; Junqueira, J.C.; Scorzoni, L. Recent Advances in the Use of Galleria mellonella Model to Study Immune Responses against Human Pathogens. J. Fungi 2018, 4, 128.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Fungi EISSN 2309-608X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top