An Invertebrate Host to Study Fungal Infections, Mycotoxins and Antifungal Drugs: Tenebrio molitor
AbstractFaced with ethical conflict and social pressure, researchers have increasingly chosen to use alternative models over vertebrates in their research. Since the innate immune system is evolutionarily conserved in insects, the use of these animals in research is gaining ground. This review discusses Tenebrio molitor as a potential model host for the study of pathogenic fungi. Larvae of T. molitor are known as cereal pests and, in addition, are widely used as animal and human feed. A number of studies on mechanisms of the humoral system, especially in the synthesis of antimicrobial peptides, which have similar characteristics to vertebrates, have been performed. These studies demonstrate the potential of T. molitor larvae as a model host that can be used to study fungal virulence, mycotoxin effects, host immune responses to fungal infection, and the action of antifungal compounds. View Full-Text
Share & Cite This Article
Canteri de Souza, P.; Custódio Caloni, C.; Wilson, D.; Sergio Almeida, R. An Invertebrate Host to Study Fungal Infections, Mycotoxins and Antifungal Drugs: Tenebrio molitor. J. Fungi 2018, 4, 125.
Canteri de Souza P, Custódio Caloni C, Wilson D, Sergio Almeida R. An Invertebrate Host to Study Fungal Infections, Mycotoxins and Antifungal Drugs: Tenebrio molitor. Journal of Fungi. 2018; 4(4):125.Chicago/Turabian Style
Canteri de Souza, Patrícia; Custódio Caloni, Carla; Wilson, Duncan; Sergio Almeida, Ricardo. 2018. "An Invertebrate Host to Study Fungal Infections, Mycotoxins and Antifungal Drugs: Tenebrio molitor." J. Fungi 4, no. 4: 125.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.