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J. Fungi 2018, 4(3), 112;

Tipping the Balance: C. albicans Adaptation in Polymicrobial Environments

Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut, Farmington, CT 06030, USA
Author to whom correspondence should be addressed.
Received: 29 August 2018 / Revised: 14 September 2018 / Accepted: 15 September 2018 / Published: 18 September 2018
(This article belongs to the Special Issue Cell Adhesion in Fungal Life and Pathogenesis)
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Candida albicans is a pleiomorphic fungus which co-exists with commensal bacteria in mucosal and skin sites of mammalian hosts. It is also a major co-isolated organism from polymicrobial systemic infections, with high potential for morbidity or mortality in immunocompromised patients. Traditionally, resident mucosal bacteria have been thought to antagonize C. albicans in its ability to colonize or cause infection. However, recent investigations have revealed synergistic relationships with certain bacterial species that colonize the same mucosal sites with C. albicans. Such relationships broaden the research landscape in pathogenesis but also contribute to clinical challenges in the prevention or treatment of mucosal candidiasis. This review sheds light on interactions of C. albicans and mucosal bacteria, with special emphasis on the effects of the resident bacterial microbiota on C. albicans physiology as they relate to its adaptation in mucosal sites as a commensal colonizer or as a pathogenic organism. View Full-Text
Keywords: polymicrobial interactions; Candida albicans; candidiasis; fungal-bacterial interactions polymicrobial interactions; Candida albicans; candidiasis; fungal-bacterial interactions

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Ranjan, A.; Dongari-Bagtzoglou, A. Tipping the Balance: C. albicans Adaptation in Polymicrobial Environments. J. Fungi 2018, 4, 112.

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