Next Article in Journal
The Use of Galleria mellonella Larvae to Identify Novel Antimicrobial Agents against Fungal Species of Medical Interest
Previous Article in Journal / Special Issue
Do Pentraxins Bind to Fungi in Invasive Human Gastrointestinal Candidiasis?
Article Menu
Issue 3 (September) cover image

Export Article

Open AccessReview
J. Fungi 2018, 4(3), 112; https://doi.org/10.3390/jof4030112

Tipping the Balance: C. albicans Adaptation in Polymicrobial Environments

Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut, Farmington, CT 06030, USA
*
Author to whom correspondence should be addressed.
Received: 29 August 2018 / Revised: 14 September 2018 / Accepted: 15 September 2018 / Published: 18 September 2018
(This article belongs to the Special Issue Cell Adhesion in Fungal Life and Pathogenesis)
Full-Text   |   PDF [594 KB, uploaded 18 September 2018]   |  

Abstract

Candida albicans is a pleiomorphic fungus which co-exists with commensal bacteria in mucosal and skin sites of mammalian hosts. It is also a major co-isolated organism from polymicrobial systemic infections, with high potential for morbidity or mortality in immunocompromised patients. Traditionally, resident mucosal bacteria have been thought to antagonize C. albicans in its ability to colonize or cause infection. However, recent investigations have revealed synergistic relationships with certain bacterial species that colonize the same mucosal sites with C. albicans. Such relationships broaden the research landscape in pathogenesis but also contribute to clinical challenges in the prevention or treatment of mucosal candidiasis. This review sheds light on interactions of C. albicans and mucosal bacteria, with special emphasis on the effects of the resident bacterial microbiota on C. albicans physiology as they relate to its adaptation in mucosal sites as a commensal colonizer or as a pathogenic organism. View Full-Text
Keywords: polymicrobial interactions; Candida albicans; candidiasis; fungal-bacterial interactions polymicrobial interactions; Candida albicans; candidiasis; fungal-bacterial interactions
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ranjan, A.; Dongari-Bagtzoglou, A. Tipping the Balance: C. albicans Adaptation in Polymicrobial Environments. J. Fungi 2018, 4, 112.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Fungi EISSN 2309-608X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top