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J. Fungi 2018, 4(4), 119; https://doi.org/10.3390/jof4040119

Adhesins of Yeasts: Protein Structure and Interactions

1
Alliance Research Group VUB-UGent NanoMicrobiology (NAMI), IJRG VUB-EPFL NanoBiotechnology & NanoMedicine (NANO), Research Group Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium
2
Department Bioscience Engineering, University Antwerp, 2020 Antwerp, Belgium
Received: 19 September 2018 / Revised: 23 October 2018 / Accepted: 24 October 2018 / Published: 27 October 2018
(This article belongs to the Special Issue Cell Adhesion in Fungal Life and Pathogenesis)
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Abstract

The ability of yeast cells to adhere to other cells or substrates is crucial for many yeasts. The budding yeast Saccharomyces cerevisiae can switch from a unicellular lifestyle to a multicellular one. A crucial step in multicellular lifestyle adaptation is self-recognition, self-interaction, and adhesion to abiotic surfaces. Infectious yeast diseases such as candidiasis are initiated by the adhesion of the yeast cells to host cells. Adhesion is accomplished by adhesin proteins that are attached to the cell wall and stick out to interact with other cells or substrates. Protein structures give detailed insights into the molecular mechanism of adhesin-ligand interaction. Currently, only the structures of a very limited number of N-terminal adhesion domains of adhesins have been solved. Therefore, this review focuses on these adhesin protein families. The protein architectures, protein structures, and ligand interactions of the flocculation protein family of S. cerevisiae; the epithelial adhesion family of C. glabrata; and the agglutinin-like sequence protein family of C. albicans are reviewed and discussed. View Full-Text
Keywords: yeast adhesions; Saccharomyces cerevisiae; Candida albicans; Candida glabrata; the flocculation protein family; the epithelial adhesion family; the agglutinin-like sequence protein family; Flo proteins; Als proteins; Epa proteins yeast adhesions; Saccharomyces cerevisiae; Candida albicans; Candida glabrata; the flocculation protein family; the epithelial adhesion family; the agglutinin-like sequence protein family; Flo proteins; Als proteins; Epa proteins
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Willaert, R.G. Adhesins of Yeasts: Protein Structure and Interactions. J. Fungi 2018, 4, 119.

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