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The Candida albicans Biofilm Matrix: Composition, Structure and Function

Department of Biology, University of the Incarnate Word, San Antonio, TX 78209, USA
Department of Biology and South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78294, USA
Department of Biomedical, Chemical & Materials Engineering, San José State University, San José, CA 95192, USA
Author to whom correspondence should be addressed.
Academic Editor: Mahmoud A. Ghannoum
J. Fungi 2017, 3(1), 14;
Received: 24 January 2017 / Revised: 28 February 2017 / Accepted: 3 March 2017 / Published: 8 March 2017
(This article belongs to the Special Issue Fungal Biofilms)
PDF [901 KB, uploaded 8 March 2017]


A majority of infections caused by Candida albicans—the most frequent fungal pathogen—are associated with biofilm formation. A salient feature of C. albicans biofilms is the presence of the biofilm matrix. This matrix is composed of exopolymeric materials secreted by sessile cells within the biofilm, in which all classes of macromolecules are represented, and provides protection against environmental challenges. In this review, we summarize the knowledge accumulated during the last two decades on the composition, structure, and function of the C. albicans biofilm matrix. Knowledge of the matrix components, its structure, and function will help pave the way to novel strategies to combat C. albicans biofilm infections. View Full-Text
Keywords: Candida albicans; candidiasis; biofilms; extracellular matrix; antifungal resistance Candida albicans; candidiasis; biofilms; extracellular matrix; antifungal resistance

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Pierce, C.G.; Vila, T.; Romo, J.A.; Montelongo-Jauregui, D.; Wall, G.; Ramasubramanian, A.; Lopez-Ribot, J.L. The Candida albicans Biofilm Matrix: Composition, Structure and Function. J. Fungi 2017, 3, 14.

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