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Candida glabrata Biofilms: How Far Have We Come?

CEB, Centre of Biological Engineering, LIBRO—Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, 4710-057 Braga, Portugal
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Academic Editor: Mahmoud A. Ghannoum
J. Fungi 2017, 3(1), 11; https://doi.org/10.3390/jof3010011
Received: 20 December 2016 / Revised: 7 February 2017 / Accepted: 16 February 2017 / Published: 1 March 2017
(This article belongs to the Special Issue Fungal Biofilms)
Infections caused by Candida species have been increasing in the last decades and can result in local or systemic infections, with high morbidity and mortality. After Candida albicans, Candida glabrata is one of the most prevalent pathogenic fungi in humans. In addition to the high antifungal drugs resistance and inability to form hyphae or secret hydrolases, C. glabrata retain many virulence factors that contribute to its extreme aggressiveness and result in a low therapeutic response and serious recurrent candidiasis, particularly biofilm formation ability. For their extraordinary organization, especially regarding the complex structure of the matrix, biofilms are very resistant to antifungal treatments. Thus, new approaches to the treatment of C. glabrata’s biofilms are emerging. In this article, the knowledge available on C. glabrata’s resistance will be highlighted, with a special focus on biofilms, as well as new therapeutic alternatives to control them. View Full-Text
Keywords: Candida species; Candida glabrata; biofilm; candidiasis; resistance; antifungal; infection Candida species; Candida glabrata; biofilm; candidiasis; resistance; antifungal; infection
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Rodrigues, C.F.; Rodrigues, M.E.; Silva, S.; Henriques, M. Candida glabrata Biofilms: How Far Have We Come? J. Fungi 2017, 3, 11.

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