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An Update on the Tissue Renin Angiotensin System and Its Role in Physiology and Pathology

1
EA4173, Functional genomics of arterial hypertension, Univeristy Claude Bernard Lyon-1 (UCBL-1), 69008 Lyon, France
2
Department of Pharmacology and Toxicology, Heart Repair Division, Faculty of Medicine, American University of Beirut, Beirut 11-0236, Lebanon
3
Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4
PRASE, Biology Department, Faculty of Sciences-I, Lebanese University, Beirut, Lebanon
*
Author to whom correspondence should be addressed.
J. Cardiovasc. Dev. Dis. 2019, 6(2), 14; https://doi.org/10.3390/jcdd6020014
Received: 10 February 2019 / Revised: 18 March 2019 / Accepted: 26 March 2019 / Published: 29 March 2019
(This article belongs to the Special Issue Nutrition, Genetics, and Cardiovascular Disease)
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Abstract

In its classical view, the renin angiotensin system (RAS) was defined as an endocrine system involved in blood pressure regulation and body electrolyte balance. However, the emerging concept of tissue RAS, along with the discovery of new RAS components, increased the physiological and clinical relevance of the system. Indeed, RAS has been shown to be expressed in various tissues where alterations in its expression were shown to be involved in multiple diseases including atherosclerosis, cardiac hypertrophy, type 2 diabetes (T2D) and renal fibrosis. In this chapter, we describe the new components of RAS, their tissue-specific expression, and their alterations under pathological conditions, which will help achieve more tissue- and condition-specific treatments. View Full-Text
Keywords: renin-angiotensin-aldosterone system; tissue; expression; physiology renin-angiotensin-aldosterone system; tissue; expression; physiology
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Nehme, A.; Zouein, F.A.; Deris Zayeri, Z.; Zibara, K. An Update on the Tissue Renin Angiotensin System and Its Role in Physiology and Pathology. J. Cardiovasc. Dev. Dis. 2019, 6, 14.

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