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Emerging Roles for Immune Cells and MicroRNAs in Modulating the Response to Cardiac Injury

Kathryn W. Davis Center for Regenerative Biology and Medicine, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA
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J. Cardiovasc. Dev. Dis. 2019, 6(1), 5; https://doi.org/10.3390/jcdd6010005
Received: 15 November 2018 / Revised: 4 January 2019 / Accepted: 9 January 2019 / Published: 15 January 2019
(This article belongs to the Special Issue Cardiac Regeneration in Non-Mammalian Vertebrates)
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Abstract

Stimulating cardiomyocyte regeneration after an acute injury remains the central goal in cardiovascular regenerative biology. While adult mammals respond to cardiac damage with deposition of rigid scar tissue, adult zebrafish and salamander unleash a regenerative program that culminates in new cardiomyocyte formation, resolution of scar tissue, and recovery of heart function. Recent studies have shown that immune cells are key to regulating pro-inflammatory and pro-regenerative signals that shift the injury microenvironment toward regeneration. Defining the genetic regulators that control the dynamic interplay between immune cells and injured cardiac tissue is crucial to decoding the endogenous mechanism of heart regeneration. In this review, we discuss our current understanding of the extent that macrophage and regulatory T cells influence cardiomyocyte proliferation and how microRNAs (miRNAs) regulate their activity in the injured heart. View Full-Text
Keywords: myocardial infarction; heart regeneration; macrophages; regulatory T cells; microRNAs; zebrafish; cardiomyocyte proliferation; fibrosis myocardial infarction; heart regeneration; macrophages; regulatory T cells; microRNAs; zebrafish; cardiomyocyte proliferation; fibrosis
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Rodriguez, A.M.; Yin, V.P. Emerging Roles for Immune Cells and MicroRNAs in Modulating the Response to Cardiac Injury. J. Cardiovasc. Dev. Dis. 2019, 6, 5.

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