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Covering and Re-Covering the Heart: Development and Regeneration of the Epicardium

Cardiovascular Research Institute, Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10021, USA
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J. Cardiovasc. Dev. Dis. 2019, 6(1), 3; https://doi.org/10.3390/jcdd6010003
Received: 31 October 2018 / Revised: 13 December 2018 / Accepted: 19 December 2018 / Published: 24 December 2018
(This article belongs to the Special Issue Cardiac Regeneration in Non-Mammalian Vertebrates)
The epicardium, a mesothelial layer that envelops vertebrate hearts, has become a therapeutic target in cardiac repair strategies because of its vital role in heart development and cardiac injury response. Epicardial cells serve as a progenitor cell source and signaling center during both heart development and regeneration. The importance of the epicardium in cardiac repair strategies has been reemphasized by recent progress regarding its requirement for heart regeneration in zebrafish, and by the ability of patches with epicardial factors to restore cardiac function following myocardial infarction in mammals. The live surveillance of epicardial development and regeneration using zebrafish has provided new insights into this topic. In this review, we provide updated knowledge about epicardial development and regeneration. View Full-Text
Keywords: heart development; epicardium; proepicardial organ; heart regeneration; zebrafish heart development; epicardium; proepicardial organ; heart regeneration; zebrafish
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Cao, Y.; Cao, J. Covering and Re-Covering the Heart: Development and Regeneration of the Epicardium. J. Cardiovasc. Dev. Dis. 2019, 6, 3.

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