Next Article in Journal
Veterinary Chiropractic Treatment as a Measure to Prevent the Occurrence of Spondylosis in Boxers
Next Article in Special Issue
Development of a Simple Single-Acupoint Electroacupuncture Frame and Evaluation of the Acupuncture Effect in Rabbits
Previous Article in Journal
Influence of the H1 Antihistamine Mepyramine on the Antibacterial Effect of Florfenicol in Pigs
Previous Article in Special Issue
Research Progress on the Mechanism of the Acupuncture Regulating Neuro-Endocrine-Immune Network System
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Veterinary Sciences
Volume 8
Issue 9
10.3390/vetsci8090198
vetsci-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Protective Effects of Water Extract of Fructus Ligustri Lucidi against Oxidative Stress-Related Osteoporosis In Vivo and In Vitro

by
Yi Wu
1,
Yusheng Hu
2,
Zeguang Zhao
1,
Lina Xu
1,
Ye Chen
1,
Tongtong Liu
1 and
Qin Li
1,*
1
Department of Veterinary Medicine, College of Life Science and Food Engineering, Hebei University of Engineering, Handan 056038, China
2
College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
*
Author to whom correspondence should be addressed.
Vet. Sci. 2021, 8(9), 198; https://doi.org/10.3390/vetsci8090198
Submission received: 23 June 2021 / Revised: 9 September 2021 / Accepted: 14 September 2021 / Published: 17 September 2021
(This article belongs to the Special Issue Frontiers of Herbal Medicine and Acupuncture in Veterinary Medicine)
Browse Figures
Versions Notes

Abstract

Fructus Ligustri Lucidi (FLL) is the fruit of Ligustrum lucidum Ait and is a component of many kidney-tonifying traditional Chinese medicine formulae for treating osteoporosis. Accumulating evidence has linked oxidative stress with the progression of bone diseases. The present study aimed to identify the effects of FLL on oxidative stress-related osteoporosis in vivo and in vitro. To construct animal models, we utilized d-galactose (D-gal) injection to induce oxidative stress combined with a low calcium (the exact percentage in the diet was 0.1%) diet. Thirteen-week-old Kunming female mice were gavaged with water extract of FLL for 20 days. Then, eight-month-old Kunming female mice were treated with FLL under standard administration and diet as the aged group. In vitro, MC3T3-E1 cells stimulated by H2O2 were treated with FLL for 24 h. The micro-CT results showed that the modeling approach combining oxidative stress with a low calcium diet caused low conversion type osteoporosis in mice. FLL exerted a prominent effect on preventing osteoporosis by inhibiting oxidative stress, increasing bone mineral density (BMD), improving bone microstructure, and promoting osteoblast proliferation and osteoprotegerin (OPG) protein expression; however, FLL had no therapeutic effect on bone loss in aged mice. In conclusion, FLL showed outstanding anti-bone loss ability both in vivo and in vitro and could probably be developed as a prophylactic agent for osteoporosis.
Keywords: Fructus Ligustri Lucidi; traditional Chinese medicine; bone loss; MC3T3-E1 cells; bone mineral density; micro-CT Fructus Ligustri Lucidi; traditional Chinese medicine; bone loss; MC3T3-E1 cells; bone mineral density; micro-CT

Share and Cite

MDPI and ACS Style

Wu, Y.; Hu, Y.; Zhao, Z.; Xu, L.; Chen, Y.; Liu, T.; Li, Q. Protective Effects of Water Extract of Fructus Ligustri Lucidi against Oxidative Stress-Related Osteoporosis In Vivo and In Vitro. Vet. Sci. 2021, 8, 198. https://doi.org/10.3390/vetsci8090198

AMA Style

Wu Y, Hu Y, Zhao Z, Xu L, Chen Y, Liu T, Li Q. Protective Effects of Water Extract of Fructus Ligustri Lucidi against Oxidative Stress-Related Osteoporosis In Vivo and In Vitro. Veterinary Sciences. 2021; 8(9):198. https://doi.org/10.3390/vetsci8090198

Chicago/Turabian Style

Wu, Yi, Yusheng Hu, Zeguang Zhao, Lina Xu, Ye Chen, Tongtong Liu, and Qin Li. 2021. "Protective Effects of Water Extract of Fructus Ligustri Lucidi against Oxidative Stress-Related Osteoporosis In Vivo and In Vitro" Veterinary Sciences 8, no. 9: 198. https://doi.org/10.3390/vetsci8090198

APA Style

Wu, Y., Hu, Y., Zhao, Z., Xu, L., Chen, Y., Liu, T., & Li, Q. (2021). Protective Effects of Water Extract of Fructus Ligustri Lucidi against Oxidative Stress-Related Osteoporosis In Vivo and In Vitro. Veterinary Sciences, 8(9), 198. https://doi.org/10.3390/vetsci8090198

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop