Evaluation of Corpus Luteum and Plasma Progesterone the Day before Embryo Transfer as an Index for Recipient Selection in Dairy Cows
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Animal and Estrus Synchronization
2.2. Recipient Evaluation
2.3. Embryo Transfer
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Baruselli, P.S.; Ferreira, R.M.; Sales, J.N.S.; Gimenes, L.U.; Sá Filho, M.F.; Martins, C.M.; Rodrigues, C.A.; Bó, G.A. Timed embryo transfer programs for management of donor and recipient cattle. Theriogenology 2011, 76, 1583–1593. [Google Scholar] [CrossRef] [Green Version]
- Aguiar, T.S.; Araújo, C.V.; Tirloni, R.R.; Martins, L.R. Effect of Meloxicam on Pregnancy Rate of Recipient Heifers Following Transfer of In Vitro Produced Embryos. Reprod. Domest. Anim. 2013, 48, 984–988. [Google Scholar] [CrossRef] [PubMed]
- Alkan, H.; Karaşahin, T.; Dursun, Ş.; Satılmış, F.; Erdem, H.; Güler, M. Evaluation of the factors that affect the pregnancy rates during embryo transfer in beef heifers. Reprod. Domest. Anim. 2020, 55, 421–428. [Google Scholar] [CrossRef] [PubMed]
- Roper, D.A.; Schrick, F.N.; Edwards, J.L.; Hopkins, F.M.; Prado, T.M.; Wilkerson, J.B.; Saxton, A.M.; Young, C.D.; Smith, W.B. Factors in cattle affecting embryo transfer pregnancies in recipient animals. Anim. Reprod. Sci. 2018, 199, 79–83. [Google Scholar] [CrossRef]
- Rivera, F.A.; Mendonca, L.G.; Lopes, G.; Santos, J.E.; Perez, R.V.; Amstalden, M.; Correa-Calderon, A.; Chebel, R.C. Reduced progesterone concentration during growth of the first follicular wave affects embryo quality but has no effect on embryo survival post transfer in lactating dairy cows. Reproduction 2011, 141, 333. [Google Scholar] [CrossRef]
- Wiltbank, M.C.; Souza, A.H.; Carvalho, P.D.; Cunha, A.P.; Giordano, J.O.; Fricke, P.M.; Baez, G.M.; Diskin, M.G. Physiological and practical effects of progesterone on reproduction in dairy cattle. Animal 2014, 8, 70–81. [Google Scholar] [CrossRef] [Green Version]
- Forde, N.; Beltman, M.E.; Duffy, G.B.; Duffy, P.; Mehta, J.P.; Ó’Gaora, P.; Roche, J.F.; Lonergan, P.; Crowe, M.A. Changes in the Endometrial Transcriptome During the Bovine Estrous Cycle: Effect of Low Circulating Progesterone and Consequences for Conceptus Elongation. Biol. Reprod. 2011, 84, 266–278. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Carter, F.; Forde, N.; Duffy, P.; Wade, M.; Fair, T.; Crowe, M.A.; Evans, A.C.O.; Kenny, D.A.; Roche, J.F.; Lonergan, P. Effect of increasing progesterone concentration from Day 3 of pregnancy on subsequent embryo survival and development in beef heifers. Reprod. Fertil. Dev. 2008, 20, 368–375. [Google Scholar] [CrossRef]
- Garrett, J.E.; Geisert, R.D.; Zavy, M.T.; Morgan, G.L. Evidence for maternal regulation of early conceptus growth and development in beef cattle. Reproduction 1988, 84, 437–446. [Google Scholar] [CrossRef]
- Lonergan, P.; Sánchez, J.M. Symposium review: Progesterone effects on early embryo development in cattle. J. Dairy Sci. 2020, 103, 8698–8707. [Google Scholar] [CrossRef]
- Mann, G.; Lamming, G. Relationship between maternal endocrine environment, early embryo development and inhibition of the luteolytic mechanism in cows. Reproduction 2001, 121, 175–180. [Google Scholar] [CrossRef] [PubMed]
- Berg, D.K.; van Leeuwen, J.; Beaumont, S.; Berg, M.; Pfeffer, P.L. Embryo loss in cattle between Days 7 and 16 of pregnancy. Theriogenology 2010, 73, 250–260. [Google Scholar] [CrossRef] [PubMed]
- Dunne, L.D.; Diskin, M.G.; Sreenan, J.M. Embryo and foetal loss in beef heifers between day 14 of gestation and full term. Anim. Reprod. Sci. 2000, 58, 39–44. [Google Scholar] [CrossRef] [PubMed]
- Ohara, A.; Mori, T.; Taii, S.; Ban, C.; Narimoto, K. Functional Differentiation in Steroidogenesis of Two Types of Luteal Cells Isolated from Mature Human Corpora Lutea of Menstrual Cycle. J. Clin. Endocrinol. Metab. 1987, 65, 1192–1200. [Google Scholar] [CrossRef]
- Niles, A.M.; Fricke, H.P.; Carvalho, P.D.; Wiltbank, M.C.; Hernandez, L.L.; Fricke, P.M. Effect of treatment with human chorionic gonadotropin 7 days after artificial insemination or at the time of embryo transfer on reproductive outcomes in nulliparous Holstein heifers. J. Dairy Sci. 2019, 102, 2593–2606. [Google Scholar] [CrossRef]
- Sartori, R.; Rosa, G.J.M.; Wiltbank, M.C. Ovarian Structures and Circulating Steroids in Heifers and Lactating Cows in Summer and Lactating and Dry Cows in Winter. J. Dairy Sci. 2002, 85, 2813–2822. [Google Scholar] [CrossRef] [Green Version]
- Vasconcelos, J.L.M.; Sartori, R.; Oliveira, H.N.; Guenther, J.G.; Wiltbank, M.C. Reduction in size of the ovulatory follicle reduces subsequent luteal size and pregnancy rate. Theriogenology 2001, 56, 307–314. [Google Scholar] [CrossRef]
- Schams, D.; Berisha, B. Regulation of Corpus Luteum Function in Cattle—An Overview. Reprod. Domest. Anim. 2004, 39, 241–251. [Google Scholar] [CrossRef]
- Herzog, K.; Brockhan-Lüdemann, M.; Kaske, M.; Beindorff, N.; Paul, V.; Niemann, H.; Bollwein, H. Luteal blood flow is a more appropriate indicator for luteal function during the bovine estrous cycle than luteal size. Theriogenology 2010, 73, 691–697. [Google Scholar] [CrossRef]
- Pugliesi, G.; Dalmaso de Melo, G.; Silva, J.B.; Carvalhêdo, A.S.; Lopes, E.; de Siqueira Filho, E.; Silva, L.A.; Binelli, M. Use of color-Doppler ultrasonography for selection of recipients in timed-embryo transfer programs in beef cattle. Theriogenology 2019, 135, 73–79. [Google Scholar] [CrossRef]
- Davis, J.S.; Rueda, B.R. The corpus luteum: An ovarian structure with maternal instincts and suicidal tendencies. Front. Biosci. 2002, 7, d1949–d1978. [Google Scholar] [CrossRef] [Green Version]
- Northey, D.; French, L. Effect of embryo removal and intrauterine infusion of embryonic homogenates on the lifespan of the bovine corpus luteum. J. Anim. Sci. 1980, 50, 298–302. [Google Scholar] [CrossRef]
- Ochoa, J.C.; Peñagaricano, F.; Baez, G.M.; Melo, L.F.; Motta, J.C.L.; Garcia-Guerra, A.; Meidan, R.; Pinheiro Ferreira, J.C.; Sartori, R.; Wiltbank, M.C. Mechanisms for rescue of corpus luteum during pregnancy: Gene expression in bovine corpus luteum following intrauterine pulses of prostaglandins E1 and F2α. Biol. Reprod. 2018, 98, 465–479. [Google Scholar] [CrossRef] [Green Version]
- Bisinotto, R.S.; Ribeiro, E.S.; Lima, F.S.; Martinez, N.; Greco, L.F.; Barbosa, L.F.S.P.; Bueno, P.P.; Scagion, L.F.S.; Thatcher, W.W.; Santos, J.E.P. Targeted progesterone supplementation improves fertility in lactating dairy cows without a corpus luteum at the initiation of the timed artificial insemination protocol. J. Dairy Sci. 2013, 96, 2214–2225. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Denicol, A.C.; Lopes, G.; Mendonça, L.G.D.; Rivera, F.A.; Guagnini, F.; Perez, R.V.; Lima, J.R.; Bruno, R.G.S.; Santos, J.E.P.; Chebel, R.C. Low progesterone concentration during the development of the first follicular wave reduces pregnancy per insemination of lactating dairy cows. J. Dairy Sci. 2012, 95, 1794–1806. [Google Scholar] [CrossRef] [Green Version]
- Nascimento, A.B.; Souza, A.H.; Guenther, J.N.; Costa, F.P.D.; Sartori, R.; Wiltbank, M.C. Effects of treatment with human chorionic gonadotrophin or intravaginal progesterone-releasing device after AI on circulating progesterone concentrations in lactating dairy cows. Reprod. Fertil. Dev. 2013, 25, 818–824. [Google Scholar] [CrossRef] [PubMed]
- Steichen, M.M.; Larson, J.E. Effects of supplemental progesterone using a CIDR insert on pregnancy per embryo transfer of dairy heifer recipients of embryos produced in vitro. Anim. Reprod. Sci. 2019, 203, 45–51. [Google Scholar] [CrossRef]
- Pérez-Mora, A.; Segura-Correa, J.C.; Peralta-Torres, J.A. Factors associated with pregnancy rate in fixed-time embryo transfer in cattle under humid-tropical conditions of México. Anim. Reprod. 2020, 17, e20200007. [Google Scholar] [CrossRef] [PubMed]
- Zwiefelhofer, E.M.; Macmillan, K.; Gobikrushanth, M.; Adams, G.P.; Yang, S.X.; Anzar, M.; Asai-Coakwell, M.; Colazo, M.G. Comparison of two intravaginal progesterone-releasing devices in shortened-timed artificial insemination protocols in beef cattle. Theriogenology 2021, 168, 75–82. [Google Scholar] [CrossRef]
- Bolt, D.J.; Scott, V.; Kiracofe, G.H. Plasma LH and FSH after estradiol, norgestomet and Gn-RH treatment in ovariectomized beef heifers. Anim. Reprod. Sci. 1990, 23, 263–271. [Google Scholar] [CrossRef]
- Garcia, A.; Salaheddine, M. Effect of Oestrous Synchronization with Estradiol 17β and Progesterone on Follicular Wave Dynamics in Dairy Heifers. Reprod. Domest. Anim. 2001, 36, 301–307. [Google Scholar] [CrossRef]
- Carvalho, N.A.T.; Soares, J.G.; Souza, D.C.; Maio, J.R.G.; Sales, J.N.S.; Martins Júnior, B.; Macari, R.C.; D’Occhio, M.J.; Baruselli, P.S. Ovulation synchronization with estradiol benzoate or GnRH in a timed artificial insemination protocol in buffalo cows and heifers during the nonbreeding season. Theriogenology 2017, 87, 333–338. [Google Scholar] [CrossRef] [PubMed]
- Martínez, M.F.; Kastelic, J.P.; Adams, G.P.; Cook, B.; Olson, W.O.; Mapletoft, R.J. The use of progestins in regimens for fixed-time artificial insemination in beef cattle. Theriogenology 2002, 57, 1049–1059. [Google Scholar] [CrossRef] [PubMed]
- Archbald, L.F.; Sumrall, D.P.; Tran, T.; Klapstein, E.; Risco, C.; Chavatte, P. Comparison of pregnancy rates of repeat-breeder dairy cows given gonadotropin releasing hormone at or prior to the time of insemination. Theriogenology 1993, 39, 1081–1091. [Google Scholar] [CrossRef] [PubMed]
- Stevenson, J.S.; Call, E.P.; Scoby, R.K.; Phatak, A.P. Double Insemination and Gonadotropin-Releasing Hormone Treatment of Repeat-Breeding Dairy Cattle. J. Dairy Sci. 1990, 73, 1766–1772. [Google Scholar] [CrossRef] [PubMed]
- Bényei, B.; Komlósi, I.; Pécsi, A.; Pollott, G.; Marcos, C.H.; de Oliveira Campos, A.; Lemes, M.P. The effect of internal and external factors on bovine embryo transfer results in a tropical environment. Anim. Reprod. Sci. 2006, 93, 268–279. [Google Scholar] [CrossRef]
- Hansen, P.J.; Block, J. Towards an embryocentric world: The current and potential uses of embryo technologies in dairy production. Reprod. Fertil. Dev. 2004, 16, 1–14. [Google Scholar] [CrossRef] [Green Version]
- Smith, A.K.; Grimmer, S.P. Pregnancy rates for Grade 2 embryos following administration of synthetic GnRH at the time of transfer in embryo-recipient cattle. Theriogenology 2002, 57, 2083–2091. [Google Scholar] [CrossRef]
- Sangsritavong, S.; Combs, D.K.; Sartori, R.; Armentano, L.E.; Wiltbank, M.C. High Feed Intake Increases Liver Blood Flow and Metabolism of Progesterone and Estradiol-17β in Dairy Cattle. J. Dairy Sci. 2002, 85, 2831–2842. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Sartori, R.; Haughian, J.M.; Shaver, R.D.; Rosa, G.J.M.; Wiltbank, M.C. Comparison of Ovarian Function and Circulating Steroids in Estrous Cycles of Holstein Heifers and Lactating Cows. J. Dairy Sci. 2004, 87, 905–920. [Google Scholar] [CrossRef] [Green Version]
- Hansen, P.J. Reproductive physiology of the heat-stressed dairy cow: Implications for fertility and assisted reproduction. Anim. Reprod. 2019, 16, 497–507. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Naranjo-Gómez, J.S.; Uribe-García, H.F.; Herrera-Sánchez, M.P.; Lozano-Villegas, K.J.; Rodríguez-Hernández, R.; Rondón-Barragán, I.S. Heat stress on cattle embryo: Gene regulation and adaptation. Heliyon 2021, 7, e06570. [Google Scholar] [CrossRef]
- Kim, D.; Kwon, W.-S.; Ha, J.; Kim, J.; Kim, D.; Lee, W.; Moon, J.; Yi, J. Effect of oestrus synchronisation through ovulation delay by vaccination against foot-and-mouth disease in Hanwoo (Bos taurus coreanae) cows. Vet. Med. Sci. 2023, 9, 974–981. [Google Scholar] [CrossRef] [PubMed]
- Kasimanickam, R.; Kasimanickam, V. Impact of heat stress on embryonic development during first 16 days of gestation in dairy cows. Sci. Rep. 2021, 11, 14839. [Google Scholar] [CrossRef] [PubMed]
- Ricci, A.; Carvalho, P.D.; Amundson, M.C.; Fricke, P.M. Characterization of luteal dynamics in lactating Holstein cows for 32 days after synchronization of ovulation and timed artificial insemination. J. Dairy Sci. 2017, 100, 9851–9860. [Google Scholar] [CrossRef] [PubMed]
- Perez-Marin, C. Formation of Corpora Lutea and Central Luteal Cavities and Their Relationship with Plasma Progesterone Levels and Other Metabolic Parameters in Dairy Cattle. Reprod. Domest. Anim. 2009, 44, 384–389. [Google Scholar] [CrossRef]
- Cerri, R.L.A.; Chebel, R.C.; Rivera, F.; Narciso, C.D.; Oliveira, R.A.; Amstalden, M.; Baez-Sandoval, G.M.; Oliveira, L.J.; Thatcher, W.W.; Santos, J.E.P. Concentration of progesterone during the development of the ovulatory follicle: II. Ovarian and uterine responses. J. Dairy Sci. 2011, 94, 3352–3365. [Google Scholar] [CrossRef]
- Green, J.C.; Meyer, J.P.; Williams, A.M.; Newsom, E.M.; Keisler, D.H.; Lucy, M.C. Pregnancy development from day 28 to 42 of gestation in postpartum Holstein cows that were either milked (lactating) or not milked (not lactating) after calving. Reproduction 2012, 143, 699–711. [Google Scholar] [CrossRef] [Green Version]
Candidates (n) | Recipients (n) | SR (%) | Pregnancy (n) | PR (%) | |
---|---|---|---|---|---|
Total | 165 | 139 | 84.2 | 65 | 46.8 |
CONV | 98 | 82 | 83.7 | 40 | 48.8 |
JSYNC | 67 | 57 | 85.1 | 25 | 43.9 |
Heifer | 112 | 96 | 85.7 | 53 | 55.2 * |
Cow | 53 | 43 | 81.1 | 12 | 27.9 |
September~February | 87 | 72 | 82.8 | 40 | 55.6 * |
March~August | 78 | 67 | 85.9 | 25 | 37.3 |
n | CL Size (cm) | p Value | P4 Level (ng/mL) | p Value | |
---|---|---|---|---|---|
Unselected | 18 | 1.88 ± 0.67 | 0.065 | 1.98 ± 2.15 | 0.349 |
Selected | 98 | 2.11 ± 0.58 | 2.54 ± 1.99 | ||
Unpregnant | 52 | 2.10 ± 0.68 | 0.752 | 2.25 ± 1.78 | 0.089 |
Pregnant | 46 | 2.12 ± 0.47 | 2.85 ± 2.20 |
CL-1 | CL-2 | CL-3 | Total | |
---|---|---|---|---|
P4-1 | 26.7% (4/15) | 46.2% (12/26) | 16.7% (1/6) | 36.2% (17/47) a |
P4-2 | 25.0% (1/4) | 71.4% (15/21) | 40.0% (2/5) | 60.0% (18/30) a |
P4-3 | 33.3% (1/3) | 60.0% (9/15) | 33.3% (1/3) | 52.4% (11/21) a |
Total | 27.3% (6/22) a | 58.1% (36/62) b | 28.6% (4/14) ab | 46.9% (46/98) |
Variables | OR | ±95% CI | p Value |
---|---|---|---|
Synchronization | 0.648 | 0.234–1.796 | 0.405 |
Parity | 0.246 | 0.081–0.752 | 0.014 |
Season | 5.668 | 2.002–16.045 | 0.001 |
CL size | 1.145 | 0.473–2.776 | 0.764 |
P4 level | 1.284 | 0.695–2.374 | 0.424 |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Choi, W.; Ro, Y.; Choe, E.; Hong, L.; Lee, W.; Kim, D. Evaluation of Corpus Luteum and Plasma Progesterone the Day before Embryo Transfer as an Index for Recipient Selection in Dairy Cows. Vet. Sci. 2023, 10, 262. https://doi.org/10.3390/vetsci10040262
Choi W, Ro Y, Choe E, Hong L, Lee W, Kim D. Evaluation of Corpus Luteum and Plasma Progesterone the Day before Embryo Transfer as an Index for Recipient Selection in Dairy Cows. Veterinary Sciences. 2023; 10(4):262. https://doi.org/10.3390/vetsci10040262
Chicago/Turabian StyleChoi, Woojae, Younghye Ro, Eunhui Choe, Leegon Hong, Wonyou Lee, and Danil Kim. 2023. "Evaluation of Corpus Luteum and Plasma Progesterone the Day before Embryo Transfer as an Index for Recipient Selection in Dairy Cows" Veterinary Sciences 10, no. 4: 262. https://doi.org/10.3390/vetsci10040262