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Volume 10
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10.3390/data10020011
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Data Descriptor

RNA Sequencing Dataset of Drosophila Nociceptor Translatomic Response to Injury

by
Christine M. Hale
1,
Kyle J. Beauchemin
1,
Courtney L. Brann
1,
Julie K. Moulton
1,
Ramaz Geguchadze
2,
Benjamin J. Harrison
2 and
Geoffrey K. Ganter
1,*
1
College of Arts and Sciences, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA
2
College of Osteopathic Medicine, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA
*
Author to whom correspondence should be addressed.
Data 2025, 10(2), 11; https://doi.org/10.3390/data10020011
Submission received: 12 November 2024 / Revised: 11 January 2025 / Accepted: 13 January 2025 / Published: 21 January 2025
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Abstract

To prepare to address the mechanisms of injury-induced nociceptor sensitization, we sequenced the translatome of the nociceptors of injured Drosophila larvae and those of uninjured larvae. Third-instar larvae expressing a green fluorescent protein (GFP)-tagged ribosomal subunit specifically in Class 4 dendritic arborization neurons, recognized as pickpocket-expressing primary nociceptors, via the GAL4/UAS method, were injured by ultraviolet light or sham-injured. Larvae were subjected to translating ribosome affinity purification for the GFP tag and nociceptor-specific ribosome-bound RNA was sequenced.
Keywords: allodynia; hyperalgesia; RNAseq; nociceptor; pain; sensitization allodynia; hyperalgesia; RNAseq; nociceptor; pain; sensitization

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MDPI and ACS Style

Hale, C.M.; Beauchemin, K.J.; Brann, C.L.; Moulton, J.K.; Geguchadze, R.; Harrison, B.J.; Ganter, G.K. RNA Sequencing Dataset of Drosophila Nociceptor Translatomic Response to Injury. Data 2025, 10, 11. https://doi.org/10.3390/data10020011

AMA Style

Hale CM, Beauchemin KJ, Brann CL, Moulton JK, Geguchadze R, Harrison BJ, Ganter GK. RNA Sequencing Dataset of Drosophila Nociceptor Translatomic Response to Injury. Data. 2025; 10(2):11. https://doi.org/10.3390/data10020011

Chicago/Turabian Style

Hale, Christine M., Kyle J. Beauchemin, Courtney L. Brann, Julie K. Moulton, Ramaz Geguchadze, Benjamin J. Harrison, and Geoffrey K. Ganter. 2025. "RNA Sequencing Dataset of Drosophila Nociceptor Translatomic Response to Injury" Data 10, no. 2: 11. https://doi.org/10.3390/data10020011

APA Style

Hale, C. M., Beauchemin, K. J., Brann, C. L., Moulton, J. K., Geguchadze, R., Harrison, B. J., & Ganter, G. K. (2025). RNA Sequencing Dataset of Drosophila Nociceptor Translatomic Response to Injury. Data, 10(2), 11. https://doi.org/10.3390/data10020011

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