Next Article in Journal
Additive Biomanufacturing with Collagen Inks
Next Article in Special Issue
Prospects and Challenges of Translational Corneal Bioprinting
Previous Article in Journal
Computational Modeling of the Liver Arterial Blood Flow for Microsphere Therapy: Effect of Boundary Conditions
Previous Article in Special Issue
Hepatic Differentiation of Stem Cells in 2D and 3D Biomaterial Systems
Open AccessReview

Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems

1
Department of Applied Science and Technology, Institute of Materials Physics and Engineering, Politecnico di Torino, 10129 Turin, Italy
2
Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran
*
Author to whom correspondence should be addressed.
Dedicated to the cherished memory of Vittorio Croce.
Bioengineering 2020, 7(3), 65; https://doi.org/10.3390/bioengineering7030065
Received: 12 April 2020 / Revised: 26 June 2020 / Accepted: 28 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Cell–Biomaterial Interactions)
Therapeutic advancements in the treatment of various ocular diseases is often linked to the development of efficient drug delivery systems (DDSs), which would allow a sustained release while maintaining therapeutic drug levels in the target tissues. In this way, ocular tissue/cell response can be properly modulated and designed in order to produce a therapeutic effect. An ideal ocular DDS should encapsulate and release the appropriate drug concentration to the target tissue (therapeutic but non-toxic level) while preserving drug functionality. Furthermore, a constant release is usually preferred, keeping the initial burst to a minimum. Different materials are used, modified, and combined in order to achieve a sustained drug release in both the anterior and posterior segments of the eye. After giving a picture of the different strategies adopted for ocular drug release, this review article provides an overview of the biomaterials that are used as drug carriers in the eye, including micro- and nanospheres, liposomes, hydrogels, and multi-material implants; the advantages and limitations of these DDSs are discussed in reference to the major ocular applications. View Full-Text
Keywords: ocular biomaterials; drug delivery; polymers; cell-biomaterial interaction ocular biomaterials; drug delivery; polymers; cell-biomaterial interaction
Show Figures

Figure 1

MDPI and ACS Style

Baino, F.; Kargozar, S. Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems. Bioengineering 2020, 7, 65.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop