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Open AccessReview

Prospects and Challenges of Translational Corneal Bioprinting

1
Department of Ophthalmology, RWTH Aachen University, 52074 Aachen, Germany
2
Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15260, USA
3
Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore
4
Singapore National Eye Centre, Singapore 169856, Singapore
5
Institute of Applied Medical Engineering, RWTH Aachen University, 52074 Aachen, Germany
6
DWI Leibniz Institute for Interactive Materials, 52074 Aachen, Germany
*
Authors to whom correspondence should be addressed.
Bioengineering 2020, 7(3), 71; https://doi.org/10.3390/bioengineering7030071
Received: 30 May 2020 / Revised: 1 July 2020 / Accepted: 4 July 2020 / Published: 6 July 2020
(This article belongs to the Special Issue Cell–Biomaterial Interactions)
Corneal transplantation remains the ultimate treatment option for advanced stromal and endothelial disorders. Corneal tissue engineering has gained increasing interest in recent years, as it can bypass many complications of conventional corneal transplantation. The human cornea is an ideal organ for tissue engineering, as it is avascular and immune-privileged. Mimicking the complex mechanical properties, the surface curvature, and stromal cytoarchitecure of the in vivo corneal tissue remains a great challenge for tissue engineering approaches. For this reason, automated biofabrication strategies, such as bioprinting, may offer additional spatial control during the manufacturing process to generate full-thickness cell-laden 3D corneal constructs. In this review, we discuss recent advances in bioprinting and biomaterials used for in vitro and ex vivo corneal tissue engineering, corneal cell-biomaterial interactions after bioprinting, and future directions of corneal bioprinting aiming at engineering a full-thickness human cornea in the lab. View Full-Text
Keywords: bioprinting; corneal tissue engineering; hydrogel; cell-biomaterial interaction; 3D bioprinting; corneal tissue engineering; hydrogel; cell-biomaterial interaction; 3D
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MDPI and ACS Style

Fuest, M.; Yam, G.H.-F.; Mehta, J.S.; Duarte Campos, D.F. Prospects and Challenges of Translational Corneal Bioprinting. Bioengineering 2020, 7, 71. https://doi.org/10.3390/bioengineering7030071

AMA Style

Fuest M, Yam GH-F, Mehta JS, Duarte Campos DF. Prospects and Challenges of Translational Corneal Bioprinting. Bioengineering. 2020; 7(3):71. https://doi.org/10.3390/bioengineering7030071

Chicago/Turabian Style

Fuest, Matthias; Yam, Gary H.-F.; Mehta, Jodhbir S.; Duarte Campos, Daniela F. 2020. "Prospects and Challenges of Translational Corneal Bioprinting" Bioengineering 7, no. 3: 71. https://doi.org/10.3390/bioengineering7030071

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