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Bioengineering 2018, 5(3), 53; https://doi.org/10.3390/bioengineering5030053

Radio-Fluorogenic Gel Dosimetry with Coumarin

1
Department of Radiation Oncology, OhioHealth, 330 Glessner Ave., Mansfield, OH 44903, USA
2
Department of Chemistry, College of Arts and Sciences, University of Cincinnati, Cincinnati, OH 45221, USA
3
Department of Nuclear Engineering, College of Engineering, University of Cincinnati, Cincinnati, OH 45221, USA
4
Department of Radiation Oncology, College of Medicine, University of Cincinnati, Cincinnati, OH 45221, USA
5
Department of Physics, College of Arts and Sciences, University of Cincinnati, Cincinnati, OH 45221, USA
*
Author to whom correspondence should be addressed.
Received: 8 May 2018 / Revised: 19 June 2018 / Accepted: 5 July 2018 / Published: 10 July 2018
(This article belongs to the Special Issue Bioengineering Nano and Micro-Gels for Biomedical Applications)
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Abstract

Gel dosimeters are attractive detectors for radiation therapy, with properties similar to biological tissue and the potential to visualize volumetric dose distributions. Radio-fluorogenesis is the yield of fluorescent chemical products in response to energy deposition from ionizing radiation. This report shares the development of a novel radio-fluorogenic gel (RFG) dosimeter, gelatin infused with coumarin-3-carboxlyic acid (C3CA), for the quantification of imparted energy. Aqueous solutions exposed to ionizing radiation result in the production of hydroxyl free radicals through water radiolysis. Interactions between hydroxyl free radicals and coumarin-3-carboxylic acid produce a fluorescent product. 7-hydroxy-coumarin-3-carboxylic acid has a blue (445 nm) emission following ultra-violet (UV) to near UV (365–405 nm) excitation. Effects of C3CA concentration and pH buffers were investigated. The response of the RFG was explored with respect to strength, type, and exposure rate of high-energy radiation. Results show a linear dose response relationship independent of energy and type, with a dose-rate dependency. This report demonstrates increased photo-yield with high pH and the utility of gelatin-RFG for phantom studies of radiation dosimetry. View Full-Text
Keywords: gel dosimetry; radiation dosimetry; radio-fluorogenic gel; luminescent dosimetry gel dosimetry; radiation dosimetry; radio-fluorogenic gel; luminescent dosimetry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Sandwall, P.A.; Bastow, B.P.; Spitz, H.B.; Elson, H.R.; Lamba, M.; Connick, W.B.; Fenichel, H. Radio-Fluorogenic Gel Dosimetry with Coumarin. Bioengineering 2018, 5, 53.

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