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Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data

1
Department of Toxicology “Akademik Danilo Soldatović”, University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, Serbia
2
Alternative Energies and Atomic Energy Commission—Fundamental Research Division—Interdisciplinary Research Institute of Grenoble (CEA-IRIG), University of Grenoble Alpes, F-38000 Grenoble, France
3
Laboratory of Fundamental and Applied Bioenergetics (LBFA), University of Grenoble Alpes, Inserm U1055, F-38000 Grenoble, France
4
Centre of Toxicology and Forensic Sciences, Medicine School, University of Crete, 70013 Heraklion, Greece
5
General Chemical State Laboratory of Greek Republic, 71202 Heraklion, Greece
6
Department of Pharmacology & Toxicology, Oklahoma State University Center for Health Sciences, Tulsa, OK 74107, USA
*
Author to whom correspondence should be addressed.
Toxics 2020, 8(3), 63; https://doi.org/10.3390/toxics8030063
Received: 27 July 2020 / Revised: 17 August 2020 / Accepted: 18 August 2020 / Published: 27 August 2020
(This article belongs to the Special Issue Toxic Metals, Chronic Diseases and Related Cancers)
Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of “hyperglycemic” metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance. View Full-Text
Keywords: cadmium; insulin; diabetes; hyperglycemia; hyperinsulinemia; lipogenic; β-cell toxicity cadmium; insulin; diabetes; hyperglycemia; hyperinsulinemia; lipogenic; β-cell toxicity
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MDPI and ACS Style

Buha, A.; Đukić-Ćosić, D.; Ćurčić, M.; Bulat, Z.; Antonijević, B.; Moulis, J.-M.; Goumenou, M.; Wallace, D. Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data. Toxics 2020, 8, 63.

AMA Style

Buha A, Đukić-Ćosić D, Ćurčić M, Bulat Z, Antonijević B, Moulis J-M, Goumenou M, Wallace D. Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data. Toxics. 2020; 8(3):63.

Chicago/Turabian Style

Buha, Aleksandra; Đukić-Ćosić, Danijela; Ćurčić, Marijana; Bulat, Zorica; Antonijević, Biljana; Moulis, Jean-Marc; Goumenou, Marina; Wallace, David. 2020. "Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data" Toxics 8, no. 3: 63.

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