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Toxics 2018, 6(4), 70; https://doi.org/10.3390/toxics6040070

Early, Subclinical Hematological Changes Associated with Occupational Exposure to High Levels of Nitrous Oxide

1
Student Research Committee, Shiraz University of Medical Sciences, Shiraz 71645-111, Iran
2
Department of Occupational Health Engineering, Research Center for Health Sciences, Institute of Health, School of Health, Shiraz University of Medical Sciences, Shiraz 71645-111, Iran
3
Department of Clinical Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz 71645-111, Iran
*
Author to whom correspondence should be addressed.
Received: 9 October 2018 / Revised: 14 November 2018 / Accepted: 16 November 2018 / Published: 21 November 2018
(This article belongs to the Special Issue Toxicity of Chemical Mixtures)
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Abstract

This study was undertaken to determine whether exposure of operating room personnel to inhalation anesthetics, nitrous oxide, isoflurane, and sevoflurane was associated with any hematological changes. This historical cohort study was performed in 2018 at a large public hospital in Shiraz, where 52 operating room personnel and 52 administrative staff were investigated. The blood sample was taken from all individuals for Complete Blood Count. Furthermore, demographic information was collected through questionnaires. Mean atmospheric concentrations of nitrous oxide, isoflurane, and sevoflurane, to which subjects were exposed, were 850.92, 2.40, and 0.18 ppm, respectively. The hematological parameters were within the normal range in both groups. However, the mean values of hemoglobin, hematocrit, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and red blood cell count in the exposed group were significantly lower than the control group. No significant differences were noted between the two groups as far as other hematological factors were concerned. These findings provide circumstantial evidence to further substantiate the notion that occupational exposure to inhalation anesthetics, under the exposure scenario explained in this study, is associated with subtle, subclinical, prepathologic hematological changes. Long-term consequence and ramifications of these effects require further investigation. The range of exposure levels to anesthetic gases in operating rooms. View Full-Text
Keywords: inhalation anesthetic; hematological changes; occupational exposure inhalation anesthetic; hematological changes; occupational exposure
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Amiri, F.; Neghab, M.; Shouroki, F.K.; Yousefinejad, S.; Hassanzadeh, J. Early, Subclinical Hematological Changes Associated with Occupational Exposure to High Levels of Nitrous Oxide. Toxics 2018, 6, 70.

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