Clinical Impact of Vaping
Abstract
1. Introduction
2. Vaping: How It Works
3. Molecular Mechanisms of Vaping-Induced Damage and Potential Role in Lung Carcinogenesis
3.1. Nicotine
3.2. Tetrahydrocannabinol (THC)
3.3. Flavoring Agents
4. Vaping and Cancer
4.1. Lung Cancer
4.2. Other Types of Cancer
5. Non-Oncologic Vaping-Associated Lung Injuries
5.1. Chronic Obstructive Pulmonary Disease (COPD)
5.2. Asthma
5.3. EVALI
5.4. Smoking-Related Diffuse Parenchymal Lung Diseases
6. Vaping and Cardiac Diseases
7. Perceptions and Behaviors Related to Vaping in Adolescents and Young Adults
8. Youth Cessation Policies Regarding E-Cigarettes: Prevention and Intervention Strategies
9. Effect of Vaping on Pregnancy and Fetus
10. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
ENDS | Electronic Nicotine Delivery System |
WHO | World Health Organization |
THC | Tetrahydrocannabinol |
EVALI | E-cigarette or Vaping Product Use-Associated Lung Injury |
VEA | Vitamin E acetate |
ROS | Reactive oxygen species |
IL-8 | Interleukin-8 |
COPD | Chronic obstructive pulmonary disease |
CPAP | Continuous Positive Airway Pressure |
MI | Myocardial infarction |
References
- Britton, J.; George, J.; Bauld, L.; Agrawal, S.; Moxham, J.; Arnott, D.; McNeill, A.; Hopkinson, N.S. A rational approach to e-cigarettes: Challenging ERS policy on tobacco harm reduction. Eur. Respir. J. 2020, 55, 2000166. [Google Scholar] [CrossRef]
- Caponnetto, P. Well-being and harm reduction, the consolidated reality of electronic cigarettes ten years later from this emerging phenomenon: A narrative review. Health Psychol. Res. 2021, 8, 9463. [Google Scholar] [CrossRef]
- Zohara, Z.; Abdul Jaffar Azad, A.R. Breaking the Myths Around e-Cigarettes: A Narrative Review Exploring the Impact of e-Cigarette on Human Health. Cureus 2024, 16, e72039. [Google Scholar] [CrossRef]
- Hiemstra, P.S.; Bals, R. Basic science of electronic cigarettes: Assessment in cell culture and in vivo models. Respir. Res. 2016, 17, 127. [Google Scholar] [CrossRef] [PubMed]
- Herrington, J.S.; Myers, C. Electronic cigarette solutions and resultant aerosol profiles. J. Chromatogr. A 2015, 1418, 192–199. [Google Scholar] [CrossRef] [PubMed]
- Effah, F.; Taiwo, B.; Baines, D.; Bailey, A.; Marczylo, T. Pulmonary effects of e-liquid flavors: A systematic review. J. Toxicol. Environ. Health B Crit. Rev. 2022, 25, 343–371. [Google Scholar] [CrossRef]
- Behar, R.Z.; Luo, W.; McWhirter, K.J.; Pankow, J.F.; Talbot, P. Analytical and toxicological evaluation of flavor chemicals in electronic cigarette refill fluids. Sci. Rep. 2018, 8, 8288. [Google Scholar] [CrossRef] [PubMed]
- Zar, T.; Graeber, C.; Perazella, M.A. Recognition, treatment, and prevention of propylene glycol toxicity. Semin. Dial. 2007, 20, 217–219. [Google Scholar] [CrossRef]
- McGowan, M.A.; Scheman, A.; Jacob, S.E. Propylene Glycol in Contact Dermatitis: A Systematic Review. Dermatitis 2018, 29, 6–12. [Google Scholar] [CrossRef]
- Williams, M.; Bozhilov, K.N.; Talbot, P. Analysis of the elements and metals in multiple generations of electronic cigarette atomizers. Environ. Res. 2019, 175, 156–166. [Google Scholar] [CrossRef]
- Mulder, H.A.; Stewart, J.B.; Blue, I.P.; Krakowiak, R.I.; Patterson, J.L.; Karin, K.N.; Royals, J.M.; DuPont, A.C.; Forsythe, K.E.; Poklis, J.L.; et al. Characterization of E-cigarette coil temperature and toxic metal analysis by infrared temperature sensing and scanning electron microscopy—Energy-dispersive X-ray. Inhal. Toxicol. 2020, 32, 447–455. [Google Scholar] [CrossRef] [PubMed]
- Zweier, J.L.; Kundu, T.; Eid, M.S.; Hemann, C.; Leimkühler, S.; El-Mahdy, M.A. Nicotine inhalation and metabolism triggers AOX-mediated superoxide generation with oxidative lung injury. J. Biol. Chem. 2024, 300, 107626. [Google Scholar] [CrossRef]
- Suber, T.L.; Tabary, M.; Bain, W.; Olonisakin, T.; Lockwood, K.; Xiong, Z.; Zhang, Y.; Kohli, N.; Furguiele, L.; Peñaloza, H.; et al. Oxidized phospholipid and transcriptomic signatures of THC-related vaping associated lung injury. Sci. Rep. 2024, 14, 31622. [Google Scholar] [CrossRef] [PubMed]
- Kopa-Stojak, P.N.; Pawliczak, R. Disposable electronic cigarettes—Chemical composition and health effects of their use. A systematic review. Toxicol. Mech. Methods 2025, 35, 250–261. [Google Scholar] [CrossRef]
- Kundu, A.; Sachdeva, K.; Feore, A.; Sanchez, S.; Sutton, M.; Seth, S.; Schwartz, R.; Chaiton, M. Evidence update on the cancer risk of vaping e-cigarettes: A systematic review. Tob. Induc. Dis. 2025, 23, 10-18332. [Google Scholar] [CrossRef] [PubMed]
- Goldberg Scott, S.; Feigelson, H.S.; Powers, J.D.; Clennin, M.N.; Lyons, J.A.; Gray, M.T.; Vachani, A.; Burnett-Hartman, A.N. Demographic, Clinical, and Behavioral Factors Associated with Electronic Nicotine Delivery Systems Use in a Large Cohort in the United States. Tob. Use Insights 2023, 16, 1179173X221134855. [Google Scholar] [CrossRef]
- Richmond, R.C.; Sillero-Rejon, C.; Khouja, J.N.; Prince, C.; Board, A.; Sharp, G.; Suderman, M.; Relton, C.L.; Munafò, M.; Gage, S.H. Investigating the DNA methylation profile of e-cigarette use. Clin. Epigenet. 2021, 13, 183. [Google Scholar] [CrossRef]
- Song, M.-A.; Mori, K.M.; McElroy, J.P.; Freudenheim, J.L.; Weng, D.Y.; Reisinger, S.A.; Brasky, T.M.; Wewers, M.D.; Shields, P.G. Accelerated epigenetic age, inflammation, and gene expression in lung: Comparisons of smokers and vapers with non-smokers. Clin. Epigenet. 2023, 15, 160. [Google Scholar] [CrossRef]
- Komura, M.; Sato, T.; Yoshikawa, H.; Nitta, N.A.; Suzuki, Y.; Koike, K.; Kodama, Y.; Seyama, K.; Takahashi, K. Propylene glycol, a component of electronic cigarette liquid, damages epithelial cells in human small airways. Respir. Res. 2022, 23, 216. [Google Scholar] [CrossRef]
- Effah, F.; Elzein, A.; Taiwo, B.; Baines, D.; Bailey, A.; Marczylo, T. In Vitro high-throughput toxicological assessment of e-cigarette flavors on human bronchial epithelial cells and the potential involvement of TRPA1 in cinnamon flavor-induced toxicity. Toxicology 2023, 496, 153617. [Google Scholar] [CrossRef]
- Hassan, N.H.; El-Wafaey, D.I. Histopathological scoring system role in evaluation of electronic cigarette’s impact on respiratory pathway in albino rat: Biochemical, histo-morphometric and ultrastructural study. Tissue Cell 2022, 79, 101945. [Google Scholar] [CrossRef] [PubMed]
- Muthumalage, T.; Rahman, I. Pulmonary immune response regulation, genotoxicity, and metabolic reprogramming by menthol- and tobacco-flavored e-cigarette exposures in mice. Toxicol. Sci. 2023, 193, 146–165. [Google Scholar] [CrossRef]
- Sun, Q.; Chen, D.; Raja, A.; Grunig, G.; Zelikoff, J.; Jin, C. Downregulation of stem-loop binding protein by nicotine via α7-nicotinic acetylcholine receptor and its role in nicotine-induced cell transformation. Toxicol. Sci. 2022, 189, 186–202. [Google Scholar] [CrossRef] [PubMed]
- Tellez, C.S.; Grimes, M.J.; Juri, D.E.; Do, K.; Willink, R.; Dye, W.W.; Wu, G.; Picchi, M.A.; Belinsky, S.A. Flavored E-cigarette product aerosols induce transformation of human bronchial epithelial cells. Lung Cancer 2023, 179, 107180. [Google Scholar] [CrossRef]
- Alzoubi, K.H.; Khabour, O.F.; Al-Sawalha, N.A.; Karaoghlanian, N.; Shihadeh, A.; Eissenberg, T. Time course of changes in inflammatory and oxidative biomarkers in lung tissue of mice induced by exposure to electronic cigarette aerosol. Toxicol. Rep. 2022, 9, 1484–1490. [Google Scholar] [CrossRef] [PubMed]
- Daou, M.A.Z.; Shihadeh, A.; Hashem, Y.; Bitar, H.; Kassir, A.; El-Harakeh, M.; Karaoghlanian, N.; Eid, A.A.; El-Sabban, M.; Zaatari, G.; et al. Role of diabetes in lung injury from acute exposure to electronic cigarette, heated tobacco product, and combustible cigarette aerosols in an animal model. PLoS ONE 2021, 16, e0255876. [Google Scholar] [CrossRef] [PubMed]
- Guarize, J.; Casiraghi, M.; Donghi, S.; Diotti, C.; Vanoni, N.; Romano, R.; Casadio, C.; Brambilla, D.; Maisonneuve, P.; Petrella, F.; et al. Endobronchial Ultrasound Transbronchial Needle Aspiration in Thoracic Diseases: Much More than Mediastinal Staging. Can. Respir. J. 2018, 2018, 4269798. [Google Scholar] [CrossRef]
- Pelosi, G.; Petrella, F.; Sandri, M.T.; Spaggiari, L.; Galetta, D.; Viale, G. A primary pure yolk sac tumor of the lung exhibiting CDX-2 immunoreactivity and increased serum levels of alkaline phosphatase intestinal isoenzyme. Int. J. Surg. Pathol. 2006, 14, 247–251. [Google Scholar] [CrossRef]
- Fanti, S.; Farsad, M.; Battista, G.; Monetti, F.; Montini, G.C.; Chiti, A.; Savelli, G.; Petrella, F.; Bini, A.; Nanni, C.; et al. Somatostatin receptor scintigraphy for bronchial carcinoid follow-up. Clin. Nucl. Med. 2003, 28, 548–552. [Google Scholar] [CrossRef]
- Bini, A.; Grazia, M.; Petrella, F.; Chittolini, M. Multiple chondromatous hamartomas of the lung. Interact. Cardiovasc. Thorac. Surg. 2002, 1, 78–80. [Google Scholar] [CrossRef]
- Wang, Q.; Jiang, C.; Hsu, M.L.; Wisnivesky, J.; Dowlati, A.; Boffetta, P.; Kong, C.Y. E-Cigarette Use and Lung Cancer Screening Uptake. JAMA Netw. Open 2024, 7, e2419648. [Google Scholar] [CrossRef] [PubMed]
- Chen, M.; Carmella, S.G.; Lindgren, B.R.; Luo, X.; Ikuemonisan, J.; Niesen, B.; Thomson, N.M.; Murphy, S.E.; Hatsukami, D.K.; Hecht, S.S. Increased levels of the acrolein metabolite 3-hydroxypropyl mercapturic acid in the urine of e-cigarette users. Chem. Res. Toxicol. 2023, 36, 583–588. [Google Scholar] [CrossRef] [PubMed]
- Abraham, K.; Andres, S.; Palavinskas, R.; Berg, K.; Appel, K.E.; Lampen, A. Toxicology and risk assessment of acrolein in food. Mol. Nutr. Food Res. 2011, 55, 1277–1290. [Google Scholar] [CrossRef]
- Cunningham, F.; Fiebelkorn, S.; Johnson, M.; Meredith, C. A novel application of the Margin of Exposure approach: Segregation of tobacco smoke toxicants. Food Chem. Toxicol. 2011, 49, 2921–2933. [Google Scholar] [CrossRef] [PubMed]
- Li, L.; Jiang, L.; Geng, C.; Cao, J.; Zhong, L. The role of oxidative stress in acrolein-induced DNA damage in HepG2 cells. Free Radic. Res. 2008, 42, 354–361. [Google Scholar] [CrossRef]
- Dugan, K.; Breit, S.; Okut, H.; Ablah, E. Electronic cigarette use and the diagnosis of nonmelanoma skin cancer among United States adults. Cureus 2021, 13, e19053. [Google Scholar] [CrossRef]
- Catto, J.W.; Rogers, Z.; Downing, A.; Mason, S.J.; Jubber, I.; Bottomley, S.; Conner, M.; Absolom, K.; Glaser, A. Lifestyle factors in patients with bladder cancer: A contemporary picture of tobacco smoking, electronic cigarette use, body mass index, and levels of physical activity. Eur. Urol. Focus 2023, 9, 974–982. [Google Scholar] [CrossRef]
- Austin-Datta, R.J.; Chaudhari, P.V.; Cheng, T.-Y.D.; Klarenberg, G.; Striley, C.W.; Cottler, L.B. Electronic Nicotine Delivery Systems (ENDS) use among members of a community engagement program. J. Community Health 2023, 48, 338–346. [Google Scholar] [CrossRef]
- Wharram, C.E.; Kyko, J.M.; Ruterbusch, J.J.; Beebe-Dimmer, J.L.; Schwartz, A.G.; Cote, M.L. Use of electronic cigarettes among African American cancer survivors. Cancer 2023, 129, 3334–3345. [Google Scholar] [CrossRef]
- Kamal, N.M.; Shams, N.S. The impact of tobacco smoking and electronic cigarette vaping on salivary biomarkers. A comparative study. Saudi Dent. J. 2022, 34, 404–409. [Google Scholar] [CrossRef]
- Guo, J.; Ikuemonisan, J.; Hatsukami, D.K.; Hecht, S.S. Liquid chromatography-nanoelectrospray ionization-high-resolution tandem mass spectrometry analysis of apurinic/apyrimidinic sites in oral cell DNA of cigarette smokers, e-cigarette users, and nonsmokers. Chem. Res. Toxicol. 2021, 34, 2540–2548. [Google Scholar] [CrossRef]
- Kwon, H.J.; Oh, Y.T.; Park, S.; Kim, S.S.; Park, J.; Yin, J.; Hong, J.H.; Kim, C.I.; Ryu, H.; Park, J.B.; et al. Analysis of electric cigarette liquid effect on mouse brain tumor growth through EGFR and ERK activation. PLoS ONE 2021, 16, e0256730. [Google Scholar] [CrossRef] [PubMed]
- Molony, R.D.; Wu, C.-H.; Lee, Y.-F. E-liquid exposure induces bladder cancer cells to release extracellular vesicles that promote non-malignant urothelial cell transformation. Sci. Rep. 2023, 13, 142. [Google Scholar] [CrossRef]
- Franck, C.; Budlovsky, T.; Windle, S.B.; Filion, K.B.; Eisenberg, M.J. Electronic cigarettes in North America: History, use, and implications for smoking cessation. Circulation 2014, 129, 1945–1952. [Google Scholar] [CrossRef] [PubMed]
- Krishnasamy, V.P.; Hallowell, B.D.; Ko, J.Y.; Board, A.; Hartnett, K.P.; Salvatore, P.P.; Danielson, M.; Kite-Powell, A.; Twentyman, E.; Kim, L.; et al. Update: Characteristics of a Nationwide Outbreak of E-Cigarette, or Vaping, Product Use—Associated Lung Injury—United States, August 2019–January 2020. MMWR Morb. Mortal. Wkly. Rep. 2020, 69, 90–94. [Google Scholar] [CrossRef]
- Miyashita, L.; Foley, G. E-cigarettes and respiratory health: The latest evidence. J. Physiol. 2020, 598, 5027–5038. [Google Scholar] [CrossRef] [PubMed]
- Wills, T.A.; Soneji, S.S.; Choi, K.; Jaspers, I.; Tam, E.K. E-cigarette use and respiratory disorders: An integrative review of converging evidence from epidemiological and laboratory studies. Eur. Respir. J. 2021, 57, 1901815. [Google Scholar] [CrossRef]
- Global Initiative for Asthma. 2024 GINA Main Report. Global Strategy for Asthma Management and Prevention. Available online: https://ginasthma.org/2024-report (accessed on 3 April 2025).
- Hogg, J.C.; Chu, F.; Utokaparch, S.; Woods, R.; Elliott, W.M.; Buzatu, L.; Cherniack, R.M.; Rogers, R.M.; Sciurba, F.C.; Coxson, H.O.; et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 2004, 350, 2645–2653. [Google Scholar] [CrossRef]
- Agustí, A.; Hogg, J.C. Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease. N. Engl. J. Med. 2019, 381, 1248–1256. [Google Scholar] [CrossRef]
- Salvi, S.S.; Barnes, P.J. Chronic obstructive pulmonary disease in non-smokers. Lancet 2009, 374, 733–743. [Google Scholar] [CrossRef]
- Sin, D.D.; Doiron, D.; Agusti, A.; Anzueto, A.; Barnes, P.J.; Celli, B.R.; Criner, G.J.; Halpin, D.; Han, M.K.; Martinez, F.J.; et al. Air pollution and COPD: GOLD 2023 committee report. Eur. Respir. J. 2023, 61, 2202469. [Google Scholar] [CrossRef] [PubMed]
- Xie, W.; Kathuria, H.; Galiatsatos, P.; Blaha, M.J.; Hamburg, N.M.; Robertson, R.M.; Bhatnagar, A.; Benjamin, E.J.; Stokes, A.C. Association of Electronic Cigarette Use with Incident Respiratory Conditions Among US Adults From 2013 to 2018. JAMA Netw. Open 2020, 3, e2020816. [Google Scholar] [CrossRef]
- Song, C.; Hao, X.; Critselis, E.; Panagiotakos, D. The impact of electronic cigarette use on chronic obstructive pulmonary disease: A systematic review and meta-analysis. Respir. Med. 2025, 239, 107985. [Google Scholar] [CrossRef]
- Ciccone, M.M.; Scicchitano, P.; Mitacchione, G.; Zito, A.; Gesualdo, M.; Caputo, P.; Damiani, M.F.; Sassara, M.; Favale, S.; Resta, O.; et al. Is there a correlation between OSAS duration/severity and carotid intima-media thickness? Respir. Med. 2012, 106, 740–746. [Google Scholar] [CrossRef]
- Reidel, B.; Radicioni, G.; Clapp, P.W.; Ford, A.A.; Abdelwahab, S.; Rebuli, M.E.; Haridass, P.; Alexis, N.E.; Jaspers, I.; Kesimer, M. E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion. Am. J. Respir. Crit. Care Med. 2018, 197, 492–501. [Google Scholar] [CrossRef] [PubMed]
- Ghosh, A.; Coakley, R.C.; Mascenik, T.; Rowell, T.R.; Davis, E.S.; Rogers, K.; Webster, M.J.; Dang, H.; Herring, L.E.; Sassano, M.F.; et al. Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome. Am. J. Respir. Crit. Care Med. 2018, 198, 67–76. [Google Scholar] [CrossRef]
- Garcia-Arcos, I.; Geraghty, P.; Baumlin, N.; Campos, M.; Dabo, A.J.; Jundi, B.; Cummins, N.; Eden, E.; Grosche, A.; Salathe, M.; et al. Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner. Thorax 2016, 71, 1119–1129. [Google Scholar] [CrossRef]
- Wawryk-Gawda, E.; Chylińska-Wrzos, P.; Zarobkiewicz, M.K.; Chłapek, K.; Jodłowska-Jędrych, B. Lung histomorphological alterations in rats exposed to cigarette smoke and electronic cigarette vapour. Exp. Ther. Med. 2020, 19, 2826–2832. [Google Scholar] [CrossRef] [PubMed]
- Madison, M.C.; Landers, C.T.; Gu, B.-H.; Chang, C.-Y.; Tung, H.-Y.; You, R.; Hong, M.J.; Baghaei, N.; Song, L.-Z.; Porter, P.; et al. Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine. J. Clin. Investig. 2019, 129, 4290–4304. [Google Scholar] [CrossRef]
- Islam, T.; Braymiller, J.; Eckel, S.P.; Liu, F.; Tackett, A.P.; E Rebuli, M.; Barrington-Trimis, J.; McConnell, R. Secondhand nicotine vaping at home and respiratory symptoms in young adults. Thorax 2022, 77, 663–668. [Google Scholar] [CrossRef]
- Beasley, R.; Semprini, A.; A Mitchell, E. Risk factors for asthma: Is prevention possible? Lancet 2015, 386, 1075–1085. [Google Scholar] [CrossRef] [PubMed]
- Lee, J.; Song, J.-U. Diagnostic comparison of methacholine and mannitol bronchial challenge tests for identifying bronchial hyperresponsiveness in asthma: A systematic review and meta-analysis. J. Asthma 2020, 58, 883–891. [Google Scholar] [CrossRef] [PubMed]
- Polosa, R.; Thomson, N.C. Smoking and asthma: Dangerous liaisons. Eur. Respir. J. 2013, 41, 716–726. [Google Scholar] [CrossRef] [PubMed]
- Thomson, N.; Chaudhuri, R.; Livingston, E. Asthma and cigarette smoking. Eur. Respir. J. 2004, 24, 822–833. [Google Scholar] [CrossRef]
- Li, X.; Zhang, Y.; Zhang, R.; Chen, F.; Shao, L.; Zhang, L. Association Between E-Cigarettes and Asthma in Adolescents: A Systematic Review and Meta-Analysis. Am. J. Prev. Med. 2022, 62, 953–960. [Google Scholar] [CrossRef]
- Xian, S.; Chen, Y. E-cigarette users are associated with asthma disease: A meta-analysis. Clin. Respir. J. 2021, 15, 457–466. [Google Scholar] [CrossRef]
- Allbright, K.; Villandre, J.; Alexander, L.E.C.; Zhang, M.; Benam, K.H.; Evankovich, J.; Königshoff, M.; Chandra, D. The paradox of the safer cigarette: Understanding the pulmonary effects of electronic cigarettes. Eur. Respir. J. 2024, 63, 2301494. [Google Scholar] [CrossRef]
- Crotty Alexander, L.E.; Drummond, C.A.; Hepokoski, M.; Mathew, D.; Moshensky, A.; Willeford, A.; Das, S.; Singh, P.; Yong, Z.; Lee, J.H.; et al. Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2018, 314, R834–R847. [Google Scholar] [CrossRef]
- Schier, J.G.; Meiman, J.G.; Layden, J.; Mikosz, C.A.; VanFrank, B.; King, B.A.; Salvatore, P.P.; Weissman, D.N.; Thomas, J.; Melstrom, P.C.; et al. Severe Pulmonary Disease Associated with Electronic-Cigarette–Product Use—Interim Guidance. MMWR Morb. Mortal. Wkly. Rep. 2019, 68, 787–790. [Google Scholar] [CrossRef]
- Marrocco, A.; Singh, D.; Christiani, D.C.; Demokritou, P. E-cigarette vaping associated acute lung injury (EVALI): State of science and future research needs. Crit. Rev. Toxicol. 2022, 52, 188–220. [Google Scholar] [CrossRef]
- Muise, E.D.; Gordon, R.; Steiding, J.; Sullivan, K.; A Sheils, C.; Casey, A.M. Clinical Presentation and Diagnostic Evaluation of Vaping Related Lung Injury in Youth. Respirology 2025. early view. [Google Scholar] [CrossRef]
- Layden, J.E.; Ghinai, I.; Pray, I.; Kimball, A.; Layer, M.; Tenforde, M.W.; Navon, L.; Hoots, B.; Salvatore, P.; Elderbrook, M.; et al. Pulmonary Illness Related to E-Cigarette Use in Illinois and Wisconsin—Preliminary Report. N. Engl. J. Med. 2020, 382, 903–916. [Google Scholar] [CrossRef] [PubMed]
- Siegel, D.A.; Jatlaoui, T.C.; Koumans, E.H.; Kiernan, E.A.; Layer, M.; Cates, J.E.; Kimball, A.; Weissman, D.N.; Petersen, E.E.; Reagan-Steiner, S.; et al. Update: Interim Guidance for Health Care Providers Evaluating and Caring for Patients with Suspected E-cigarette, or Vaping, Product Use Associated Lung Injury—United States, October 2019. MMWR Morb. Mortal. Wkly. Rep. 2019, 68, 919–927. [Google Scholar] [CrossRef] [PubMed]
- Aberegg, S.K.; Cirulis, M.M.; Maddock, S.D.; Freeman, A.; Keenan, L.M.; Pirozzi, C.S.; Raman, S.M.; Schroeder, J.; Mann, H.; Callahan, S.J. Clinical, Bronchoscopic, and Imaging Findings of e-Cigarette, or Vaping, Product Use–Associated Lung Injury Among Patients Treated at an Academic Medical Center. JAMA Netw. Open 2020, 3, e2019176. [Google Scholar] [CrossRef] [PubMed]
- Hariri, L.P.; Flashner, B.M.; Kanarek, D.J.; O’donnell, W.J.; Soskis, A.; Ziehr, D.R.; Frank, A.; Nandy, S.; Berigei, S.R.; Sharma, A.; et al. E-Cigarette Use, Small Airway Fibrosis, and Constrictive Bronchiolitis. NEJM Evid. 2022, 1. [Google Scholar] [CrossRef]
- Viswam, D.; Trotter, S.; Burge, P.S.; I Walters, G. Respiratory failure caused by lipoid pneumonia from vaping e-cigarettes. BMJ Case Rep. 2018, 2018, bcr2018224350. [Google Scholar] [CrossRef]
- Agustin, M.; Yamamoto, M.; Cabrera, F.; Eusebio, R. Diffuse Alveolar Hemorrhage Induced by Vaping. Case Rep. Pulmonol. 2018, 2018, 9724530. [Google Scholar] [CrossRef]
- Khan, M.S.; Khateeb, F.; Akhtar, J.; Khan, Z.; Lal, A.; Kholodovych, V.; Hammersley, J. Organizing pneumonia related to electronic cigarette use: A case report and review of literature. Clin. Respir. J. 2018, 12, 1295–1299. [Google Scholar] [CrossRef]
- Flower, M.; Nandakumar, L.; Singh, M.; Wyld, D.; Windsor, M.; Fielding, D. Respiratory bronchiolitis-associated interstitial lung disease secondary to electronic nicotine delivery system use confirmed with open lung biopsy. Respirol. Case Rep. 2017, 5, e00230. [Google Scholar] [CrossRef]
- Sommerfeld, C.G.; Weiner, D.J.; Nowalk, A.; Larkin, A. Hypersensitivity Pneumonitis and Acute Respiratory Distress Syndrome From E-Cigarette Use. Pediatrics 2018, 141, e20163927. [Google Scholar] [CrossRef]
- Zong, H.; Hu, Z.; Li, W.; Wang, M.; Zhou, Q.; Li, X.; Liu, H. Electronic cigarettes and cardiovascular disease: Epidemiological and biological links. Pflug. Arch. 2024, 476, 875–888. [Google Scholar] [CrossRef] [PubMed]
- Savko, C.; Esquer, C.; Molinaro, C.; Rokaw, S.; Shain, A.G.; Jaafar, F.; Wright, M.K.; Phillips, J.A.; Hopkins, T.; Mikhail, S.; et al. Myocardial Infarction Injury Is Exacerbated by Nicotine in Vape Aerosol Exposure. J. Am. Heart Assoc. 2025, 14, e038012. [Google Scholar] [CrossRef] [PubMed]
- Dai, W.; Shi, J.; Siddarth, P.; Carreno, J.; Kleinman, M.T.; Herman, D.A.; Arechavala, R.J.; Renusch, S.; Hasen, I.; Ting, A.; et al. Effects of Electronic Cigarette Vaping on Cardiac and Vascular Function, and Post-myocardial Infarction Remodeling in Rats. Cardiovasc. Toxicol. 2024, 24, 199–208. [Google Scholar] [CrossRef]
- Kundu, A.; Feore, A.; Sanchez, S.; Abu-Zarour, N.; Sutton, M.; Sachdeva, K.; Seth, S.; Schwartz, R.; Chaiton, M. Cardiovascular health effects of vaping e-cigarettes: A systematic review and meta-analysis. Heart 2025. [Google Scholar] [CrossRef] [PubMed]
- Kucera, C.; Ramalingam, A.; Srivastava, S.; Bhatnagar, A.; Carll, A.P. Nicotine Formulation Influences the Autonomic and Arrhythmogenic Effects of Electronic Cigarettes. Nicotine Tob. Res. 2024, 26, 536–544. [Google Scholar] [CrossRef]
- Yacoub, M.I.; Aslanoğlu, A.; Khraim, F.; Alsharawneh, A.; Abdelkader, R.; Almagharbeh, W.T.; Alhejaili, A.A.; Alshahrani, B.D.; Sobeh, D.E.; Eltayeb, M.M.; et al. Comparing E-Cigarettes and Traditional Cigarettes in Relation to Myocardial Infarction, Arrhythmias, and Sudden Cardiac Death: A Systematic Review and Meta-Analysis. Biol. Res. Nurs. 2025, 27, 168–185. [Google Scholar] [CrossRef]
- Chen, C.; Huo, C.; Mattey-Mora, P.P.; Bidulescu, A.; Parker, M.A. Assessing the association between e-cigarette use and cardiovascular disease: A meta-analysis of exclusive and dual use with combustible cigarettes. Addict. Behav. 2024, 157, 108086. [Google Scholar] [CrossRef]
- Bajaña, M.J.F.; Zevallos, J.C.; Chérrez-Ojeda, I.; Alvarado, G.; Green, T.; Kirimi, B.; Jaramillo, D.; Felix, M.; Vanegas, E.; Farfan, A.; et al. Association between the use of electronic cigarettes and myocardial infarction in U.S. adults. BMC Public Health 2024, 24, 2110. [Google Scholar] [CrossRef]
- Visseren, F.L.J.; Mach, F.; Smulders, Y.M.; Carballo, D.; Koskinas, K.C.; Bäck, M.; Benetos, A.; Biffi, A.; Boavida, J.-M.; Capodanno, D.; et al. ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur. Heart J. 2021, 42, 3227–3337, Erratum in Eur. Heart J. 2022, 43, 4468. https://doi.org/10.1093/eurheartj/ehac458. [Google Scholar] [CrossRef]
- Kavousi, M.; Pisinger, C.; Barthelemy, J.-C.; De Smedt, D.; Koskinas, K.; Marques-Vidal, P.; Panagiotakos, D.; Prescott, E.B.; Tiberi, M.; Vassiliou, V.S.; et al. Electronic cigarettes and health with special focus on cardiovascular effects: Position paper of the European Association of Preventive Cardiology (EAPC). Eur. J. Prev. Cardiol. 2021, 28, 1552–1566. [Google Scholar] [CrossRef]
- World Health Organization. WHO Clinical Treatment Guideline for Tobacco Cessation in Adults; World Health Organization: Geneva, Switzerland, 2024; ISBN 978-92-4-009643-1. Available online: https://www.who.int/publications/i/item/9789240096431 (accessed on 7 April 2025).
- Biles, J.; Kornhaber, R.; Irwin, P.; Schineanu, A.; Sookraj-Baran, M.K.; Cleary, M. Perspectives, motivations, and experiences of adolescents and young adults using nicotine vapes: A qualitative review. Health Promot. Int. 2025, 40, daaf007. [Google Scholar] [CrossRef] [PubMed]
- Vilcassim, M.J.R.; Stowe, S.; Majumder, R.; Subramaniam, A.; Sinkey, R.G. Electronic Cigarette Use during Pregnancy: Is It Harmful? Toxics 2023, 11, 278. [Google Scholar] [CrossRef]
- Deprato, A.; Garud, A.; Azzolina, D.; Murgia, N.; Davenport, M.H.; Kaul, P.; Lacy, P.; Moitra, S. Associations between vaping during pregnancy and perinatal outcomes: A systematic review and meta-analysis. J. Hazard. Mater. 2025, 486, 137028. [Google Scholar] [CrossRef]
- Ndeke, J.M.; Klaunig, J.E.; Commodore, S. Nicotine or marijuana vaping exposure during pregnancy and altered immune responses in offspring. J. Environ. Expo. Assess. 2024, 3, 11. [Google Scholar] [CrossRef]
- Noël, A.; Yilmaz, S.; Farrow, T.; Schexnayder, M.; Eickelberg, O.; Jelesijevic, T. Sex-Specific Alterations of the Lung Transcriptome at Birth in Mouse Offspring Prenatally Exposed to Vanilla-Flavored E-Cigarette Aerosols and Enhanced Susceptibility to Asthma. Int. J. Environ. Res. Public Health 2023, 20, 3710. [Google Scholar] [CrossRef] [PubMed]
- Orzabal, M.R.; Naik, V.D.; Lee, J.; Hillhouse, A.E.; Brashear, W.A.; Threadgill, D.W.; Ramadoss, J. Impact of E-cig aerosol vaping on fetal and neonatal respiratory development and function. Transl. Res. 2022, 246, 102–114. [Google Scholar] [CrossRef] [PubMed]
- Mills, A.; Nassabeh, S.; Hurley, A.; Shouldis, L.; Chantler, P.D.; Dakhlallah, D.; Olfert, I.M. Influence of gestational window on offspring vascular health in rodents with in utero exposure to electronic cigarettes. J. Physiol. 2024, 602, 4271–4289. [Google Scholar] [CrossRef]
- Sailer, S.; Sebastiani, G.; Andreu-Férnández, V.; García-Algar, O. Impact of Nicotine Replacement and Electronic Nicotine Delivery Systems on Fetal Brain Development. Int. J. Environ. Res. Public Health 2019, 16, 5113. [Google Scholar] [CrossRef]
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Petrella, F.; Faverio, P.; Cara, A.; Cassina, E.M.; Libretti, L.; Torto, S.L.; Pirondini, E.; Raveglia, F.; Spinelli, F.; Tuoro, A.; et al. Clinical Impact of Vaping. Toxics 2025, 13, 470. https://doi.org/10.3390/toxics13060470
Petrella F, Faverio P, Cara A, Cassina EM, Libretti L, Torto SL, Pirondini E, Raveglia F, Spinelli F, Tuoro A, et al. Clinical Impact of Vaping. Toxics. 2025; 13(6):470. https://doi.org/10.3390/toxics13060470
Chicago/Turabian StylePetrella, Francesco, Paola Faverio, Andrea Cara, Enrico Mario Cassina, Lidia Libretti, Sara Lo Torto, Emanuele Pirondini, Federico Raveglia, Francesca Spinelli, Antonio Tuoro, and et al. 2025. "Clinical Impact of Vaping" Toxics 13, no. 6: 470. https://doi.org/10.3390/toxics13060470
APA StylePetrella, F., Faverio, P., Cara, A., Cassina, E. M., Libretti, L., Torto, S. L., Pirondini, E., Raveglia, F., Spinelli, F., Tuoro, A., Perger, E., & Luppi, F. (2025). Clinical Impact of Vaping. Toxics, 13(6), 470. https://doi.org/10.3390/toxics13060470