Next Article in Journal
Residues of Fluoroquinolone Antibiotics Induce Carbonylation and Reduce In Vitro Digestion of Sarcoplasmic and Myofibrillar Beef Proteins
Next Article in Special Issue
Exploiting Milling By-Products in Bread-Making: The Case of Sprouted Wheat
Previous Article in Journal
Dietary Grape Pomace Supplementation in Dairy Cows: Effect on Nutritional Quality of Milk and Its Derived Dairy Products
Previous Article in Special Issue
Biochemical Properties of Polyphenol Oxidases from Ready-to-Eat Lentil (Lens culinaris Medik.) Sprouts and Factors Affecting Their Activities: A Search for Potent Tools Limiting Enzymatic Browning
Article

Chemopreventive Effect of the Germinated Oat and Its Phenolic-AVA Extract in Azoxymethane/Dextran Sulfate Sodium (AOM/DSS) Model of Colon Carcinogenesis in Mice

1
Research and Graduate Studies in Food Science, School of Chemistry, Autonomous University of Queretaro, Cerro de las Campanas S/N, Querétaro 76010, Mexico
2
School of Natural Sciences, Autonomous University of Queretaro, Av. de las Ciencias S/N, Juriquilla, Querétaro 76230, Mexico
3
TECNM/Instituto Tecnológico de Durango, Felipe Pescador 1830 Ote., Durango 34080, Mexico
4
Institute of Neurobiology, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Querétaro 76230, Mexico
*
Author to whom correspondence should be addressed.
Foods 2020, 9(2), 169; https://doi.org/10.3390/foods9020169
Received: 21 January 2020 / Revised: 6 February 2020 / Accepted: 6 February 2020 / Published: 10 February 2020
(This article belongs to the Special Issue Advances in Production, Properties and Applications of Sprouted Seeds)
The consumption of fruits, vegetables, nuts, legumes, and whole grains has been associated with a lower risk of colorectal cancer (CRC) due to the content of natural compounds with antioxidant and anticancer activities. The oat (Avena sativa L.) is a unique source of avenanthramides (AVAs), among other compounds, with chemopreventive effects. In addition, oat germination has shown enhanced nutraceutical and phytochemical properties. Therefore, our objective was to evaluate the chemopreventive effect of the sprouted oat (SO) and its phenolic-AVA extract (AVA) in azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model. Turquesa oat seeds were germinated (five days at 25 °C and 60% relative humidity) and, after 16 weeks of administration, animals in the SO- and AVA-treated groups had a significantly lower inflammation grade and tumor (38–50%) and adenocarcinoma (38–63%) incidence compared to those of the AOM+DSS group (80%). Although both treatments normalized colonic GST and NQO1 activities as well as erythrocyte GSH levels, and significantly reduced cecal and colonic β-GA, thus indicating an improvement in the intestinal parameters, the inflammatory states, and the redox states of the animals, SO exerted a superior chemopreventive effect, probably due to the synergistic effects of multiple compounds. Our results indicate that oats retain their biological properties even after the germination process. View Full-Text
Keywords: germinated oat; avenanthramides; colorectal cancer; chemoprevention germinated oat; avenanthramides; colorectal cancer; chemoprevention
Show Figures

Graphical abstract

MDPI and ACS Style

Damazo-Lima, M.; Rosas-Pérez, G.; Reynoso-Camacho, R.; Pérez-Ramírez, I.F.; Rocha-Guzmán, N.E.; de los Ríos, E.A.; Ramos-Gomez, M. Chemopreventive Effect of the Germinated Oat and Its Phenolic-AVA Extract in Azoxymethane/Dextran Sulfate Sodium (AOM/DSS) Model of Colon Carcinogenesis in Mice. Foods 2020, 9, 169. https://doi.org/10.3390/foods9020169

AMA Style

Damazo-Lima M, Rosas-Pérez G, Reynoso-Camacho R, Pérez-Ramírez IF, Rocha-Guzmán NE, de los Ríos EA, Ramos-Gomez M. Chemopreventive Effect of the Germinated Oat and Its Phenolic-AVA Extract in Azoxymethane/Dextran Sulfate Sodium (AOM/DSS) Model of Colon Carcinogenesis in Mice. Foods. 2020; 9(2):169. https://doi.org/10.3390/foods9020169

Chicago/Turabian Style

Damazo-Lima, Margarita, Guadalupe Rosas-Pérez, Rosalía Reynoso-Camacho, Iza F. Pérez-Ramírez, Nuria E. Rocha-Guzmán, Ericka A. de los Ríos, and Minerva Ramos-Gomez. 2020. "Chemopreventive Effect of the Germinated Oat and Its Phenolic-AVA Extract in Azoxymethane/Dextran Sulfate Sodium (AOM/DSS) Model of Colon Carcinogenesis in Mice" Foods 9, no. 2: 169. https://doi.org/10.3390/foods9020169

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop