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Article

Assessment of a New GC-MS/MS System for the Confirmatory Measurement of PCDD/Fs and (N)DL-PCBs in Food under EU Regulation

1
Molecular Systems Research Unit, Faculty of Sciences, University of Liege, B-4000 Liege, Belgium
2
Institute of Chemistry, Federal University of Rio Grande do Sul, 90040-060 Porto Alegre, Brazil
*
Author to whom correspondence should be addressed.
Contributed equally to the work.
Foods 2019, 8(8), 302; https://doi.org/10.3390/foods8080302
Received: 12 July 2019 / Revised: 26 July 2019 / Accepted: 28 July 2019 / Published: 1 August 2019
(This article belongs to the Special Issue Rapid Detection Methods for Food Fraud and Food Contaminants)
Polychlorodibenzo-p-dioxins (PCDDs), polychloro-dibenzofurans (PCDFs), dioxin-like (DL), and non dioxin-like (NDL) polychlorinated biphenyls (PCBs) are currently regulated in food and feed within the European territory (EU 2017/644-771). The confirmatory methods of analysis for checking compliance with maximum levels (MLs) for these involve either the historically-established GC-magnetic sector high-resolution mass spectrometry (GC-HRMS) and, more recently, GC-triple quadrupole mass spectrometry operating in tandem mode (GC-QQQMS/MS). In this study, the performance of a novel triple quadrupole GC-QQQMS/MS system equipped with a programable temperature vaporization (PTV) injector was evaluated for the analysis of regulated PCDD/Fs and PCBs in food and feed. The MS analyzer was equipped with a titanium ionization chamber and a new short collision cell capable to accumulate and eject ions by means of very narrow pulses that allow to minimize the noise and to adapt accumulation times for sensitive multiple reaction monitoring (MRM). The analytical capability of the system was confronted by the strict requirements (selectivity, reproducibility, linearity, quant/qual MRM transitions, accuracy, robustness) set by the EU Regulation for a range of standards, quality control (QC) and food/feed samples. In this respect, the approach showed high precision (1.9–15% relative standard deviation (RSD) at low pg/µL) and accuracy (>80%, except for one hexa-CDD). The quantitative results were also compared to the most used GC-HRMS. In this case, comparable results in terms of single congener concentration basis and total toxic equivalent (TEQ) basis for PCDD/Fs and DL-PCBs were obtained for the QC samples analyzed. View Full-Text
Keywords: targeted analysis; food contaminants; food safety; tandem mass spectrometry (MS/MS); gas chromatography (GC); method validation targeted analysis; food contaminants; food safety; tandem mass spectrometry (MS/MS); gas chromatography (GC); method validation
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MDPI and ACS Style

Franchina, F.A.; Lazzari, E.; Scholl, G.; Focant, J.-F. Assessment of a New GC-MS/MS System for the Confirmatory Measurement of PCDD/Fs and (N)DL-PCBs in Food under EU Regulation. Foods 2019, 8, 302. https://doi.org/10.3390/foods8080302

AMA Style

Franchina FA, Lazzari E, Scholl G, Focant J-F. Assessment of a New GC-MS/MS System for the Confirmatory Measurement of PCDD/Fs and (N)DL-PCBs in Food under EU Regulation. Foods. 2019; 8(8):302. https://doi.org/10.3390/foods8080302

Chicago/Turabian Style

Franchina, Flavio A., Eliane Lazzari, George Scholl, and Jean-François Focant. 2019. "Assessment of a New GC-MS/MS System for the Confirmatory Measurement of PCDD/Fs and (N)DL-PCBs in Food under EU Regulation" Foods 8, no. 8: 302. https://doi.org/10.3390/foods8080302

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