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Maternal Consumption of a Diet Rich in Maillard Reaction Products Accelerates Neurodevelopment in F1 and Sex-Dependently Affects Behavioral Phenotype in F2 Rat Offspring

1
Institute of Molecular Biomedicine, Medical Faculty, Comenius University, 81108 Bratislava, Slovakia
2
Department of Biology, Faculty of Medicine, Slovak Medical University, 83303 Bratislava, Slovakia
3
Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, 81108 Bratislava, Slovakia
4
Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy
*
Author to whom correspondence should be addressed.
Foods 2019, 8(5), 168; https://doi.org/10.3390/foods8050168
Received: 28 April 2019 / Revised: 13 May 2019 / Accepted: 14 May 2019 / Published: 17 May 2019
(This article belongs to the Special Issue Browning Reactions in Foods. Impact on Nutrition, Safety and Health)
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Abstract

Thermal processing of foods at temperatures > 100 °C introduces considerable amounts of advanced glycation end-products (AGEs) into the diet. Maternal dietary exposure might affect the offspring early development and behavioral phenotype in later life. In a rat model, we examined the influence of maternal (F0) dietary challenge with AGEs-rich diet (AGE-RD) during puberty, pregnancy and lactation on early development, a manifestation of physiological reflexes, and behavioral phenotype of F1 and F2 offspring. Mean postnatal day of auditory conduit and eye opening, or incisor eruption was not affected by F0 diet significantly. F1 AGE-RD offspring outperformed their control counterparts in hind limb placing, in grasp tests and surface righting; grandsons of AGE-RD dams outperformed their control counterparts in hind limb placing and granddaughters in surface righting. In a Morris water maze, female AGE-RD F1 and F2 offspring presented better working memory compared with a control group of female offspring. Furthermore, male F2 AGE-RD offspring manifested anxiolysis-like behavior in a light dark test. Mean grooming time in response to sucrose splash did not differ between dietary groups. Our findings indicate that long-term maternal intake of AGE-RD intergenerationally and sex-specifically affects development and behavioral traits of offspring which have never come into direct contact with AGE-RD. View Full-Text
Keywords: dietary advanced glycation end products; rat; pregnancy; lactation; second generation; physiological reflexes; locomotion; exploratory behavior; anxiety-like behavior dietary advanced glycation end products; rat; pregnancy; lactation; second generation; physiological reflexes; locomotion; exploratory behavior; anxiety-like behavior
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Csongová, M.; Renczés, E.; Šarayová, V.; Mihalovičová, L.; Janko, J.; Gurecká, R.; Troise, A.D.; Vitaglione, P.; Šebeková, K. Maternal Consumption of a Diet Rich in Maillard Reaction Products Accelerates Neurodevelopment in F1 and Sex-Dependently Affects Behavioral Phenotype in F2 Rat Offspring. Foods 2019, 8, 168.

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