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Salivary Cortisol Levels in Patients with Oral Lichen Planus—A Pilot Case-Control Study

Department of Oral Medicine, University Clinical Hospital Center Zagreb, 10000 Zagreb, Croatia
Department of Nuclear Medicine and Oncology, University Clinical Hospital Sisters of Mercy, 10000 Zagreb, Croatia
Department of Oral Medicine, School of Dental Medicine University of Zagreb, 10000 Zagreb, Croatia
Author to whom correspondence should be addressed.
Dent. J. 2019, 7(2), 59;
Received: 8 April 2019 / Revised: 25 April 2019 / Accepted: 3 May 2019 / Published: 1 June 2019
(This article belongs to the Special Issue Oral Medicine)
PDF [183 KB, uploaded 1 June 2019]


It is known that cortisol level increases in stress situations. The aim of the study was to measure the levels of salivary cortisol in patients with oral lichen planus (OLP) and healthy controls. This was a case-control pilot study which included seven patients with reticular (non-symptomatic) OLP, eight patients with atrophic/erosive (symptomatic) OLP, and nine healthy controls. We hypothesized that patients with an atrophic/erosive type of OLP have higher levels of cortisol compared to patients with the reticular type of OLP and healthy controls. In each participant, unstimulated saliva was collected in order to determine cortisol levels by using commercially available ELISA kit. Our results have shown no differences between levels of salivary cortisol in OLP patients and healthy controls. We can conclude that further research with a larger number of OLP patients is needed to determine the correlation between OLP and stress. View Full-Text
Keywords: oral lichen planus; saliva; cortisol; stress oral lichen planus; saliva; cortisol; stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Skrinjar, I.; Vidranski, V.; Brzak, B.L.; Vidovic Juras, D.; Andabak Rogulj, A.; Brailo, V.; Vucicevic Boras, V. Salivary Cortisol Levels in Patients with Oral Lichen Planus—A Pilot Case-Control Study. Dent. J. 2019, 7, 59.

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