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Effect of Dietary Fiber on the Composition of the Murine Dental Microbiome

1
Department of BioMedical Sciences, School of Medicine, Mercer University, Macon, GA 31207, USA
2
Department of Biology, Mercer University, Macon, GA 31207, USA
3
Department of Biology, Frostburg State University, Frostburg, MD 21532-2303, USA
4
Research Resources Center, University of Illinois at Chicago, Chicago, IL 60612-3748, USA
*
Author to whom correspondence should be addressed.
Dent. J. 2019, 7(2), 58; https://doi.org/10.3390/dj7020058
Received: 22 March 2019 / Revised: 25 April 2019 / Accepted: 13 May 2019 / Published: 1 June 2019
(This article belongs to the Special Issue Oral Health to Global Health: Impact of Nutrition)
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Abstract

The oral cavity houses a diverse consortium of microorganisms, heavily influenced by host diet, that can mediate dental health and disease. While the impact of dietary carbohydrates to the dental microbiome has been well-documented, the effect of fiber as a mechanical influence on the dental microbiome is unexplored. We performed 16S rRNA gene analysis to investigate the response of the dental microbiome to the presence of increased fiber in terms of microbial taxonomic abundance and diversity. Dental microbial community structure was significantly different in mice fed a diet supplemented with increased fiber and/or sugar. Fiber significantly affected measures of beta diversity at the phylum and genus levels, and a strong interactive effect on alpha diversity was observed between sugar and fiber at the phylum level. The addition of fiber also induced significant variation in relative taxonomic abundance. This study demonstrates that fiber can promote significant variations in the mouse dental microbiome. View Full-Text
Keywords: dental microbiome; dietary sugar; dietary fiber; 16S; biofilm dental microbiome; dietary sugar; dietary fiber; 16S; biofilm
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Sedghi, L.; Byron, C.; Jennings, R.; Chlipala, G.E.; Green, S.J.; Silo-Suh, L. Effect of Dietary Fiber on the Composition of the Murine Dental Microbiome. Dent. J. 2019, 7, 58.

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